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The asymmetric distribution of phospholipids in bovine endothelial-cell membranes was probed with 2,4,6-trinitrobenzenesulphonate and purified phospholipase A2. The data suggest that phosphotidylethanolamine is primarily located in the inner lipid bilayer, as reported for other cell types. Stearic acid is taken up by the endothelial cells and is randomly distributed among the membrane phospholipids. In contrast, the polyunsaturated fatty acids (arachidonic, eicosatrienoic and eicosapentaenoic acids) have initial incorporation into the phosphatidylcholine fraction. These fatty acids then undergo a time-dependent transfer from phosphatidylcholine to phosphatidylethanolamine. Thus we propose that endothelial cells possess a mechanism for the selective internalization of polyunsaturated fatty acids.
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
July 1996,
European journal of immunology,
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
April 1989,
Investigative ophthalmology & visual science,
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
August 1986,
Journal of applied physiology (Bethesda, Md. : 1985),
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
June 1985,
Experimental cell research,
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
June 1986,
Thrombosis and haemostasis,
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
January 1983,
Arteriosclerosis (Dallas, Tex.),
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
October 1992,
The American journal of physiology,
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
January 1982,
Annals of the New York Academy of Sciences,
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
January 1981,
Progress in lipid research,
E R Hall, and
C E Manner, and
J Carinhas, and
R Snopko, and
M Rafelson
January 1999,
Journal of vascular research,
