Antiparasitic activity of 1,3-dioxolanes containing tellurium in Trichomonas vaginalis. 2017

Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS 96010-900, Brazil. Electronic address: angelasena@ymail.com.

The increased prevalence of metronidazole-resistant infections has resulted in a search for alternative drugs for the treatment of trichomoniasis. In the present study, we report the preparation and in vitro activity of three 1,3-dioxolanes that contain tellurium (PTeDOX 01, PTeDOX 02, and PTeDOX 03) against Trichomonas vaginalis. Six concentrations of these compounds were analyzed for in vitro activity against ATCC 30236 isolate of T. vaginalis. PTeDOX 01 reported a cytotoxic effect against 100% of T. vaginalis trophozoites at a final concentration of 90μM with an IC50 of 60μM. The kinetic growth curve of trophozoites indicated that PTeDOX 01 reduced the growth by 22% at a concentration of 90μM after an exposure of 12h, and induced complete parasite death at 24h. It induced cytotoxicity of 44% at 90μM concentration but and had no effect in lower concentrations in a culture of CHO-K1 cells. These results confirmed that PTeDOX 01 is an important drug for the treatment of T. vaginalis, and should be evaluated in other infectious agents as well.

UI MeSH Term Description Entries
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D003412 Cricetulus A genus of the family Muridae consisting of eleven species. C. migratorius, the grey or Armenian hamster, and C. griseus, the Chinese hamster, are the two species used in biomedical research. Hamsters, Armenian,Hamsters, Chinese,Hamsters, Grey,Armenian Hamster,Armenian Hamsters,Chinese Hamster,Chinese Hamsters,Grey Hamster,Grey Hamsters,Hamster, Armenian,Hamster, Chinese,Hamster, Grey
D004148 Dioxolanes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000977 Antiparasitic Agents Drugs used to treat or prevent parasitic infections. Antiparasitic,Antiparasitic Agent,Antiparasitic Drug,Parasiticide,Parasiticides,Antiparasitic Drugs,Antiparasitics,Agent, Antiparasitic,Agents, Antiparasitic,Drug, Antiparasitic,Drugs, Antiparasitic
D013691 Tellurium An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.
D014245 Trichomonas Infections Infections in birds and mammals produced by various species of Trichomonas. Infections, Trichomonas,Trichomoniasis,Infection, Trichomonas,Trichomonas Infection,Trichomoniases
D014246 Trichomonas vaginalis A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males. Trichomonas vaginali,vaginali, Trichomonas
D016466 CHO Cells CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells. CHO Cell,Cell, CHO,Cells, CHO
D053058 Trophozoites Cells or feeding stage in the life cycle of sporozoan protozoa. In the malarial parasite, the trophozoite develops from the MEROZOITE and then splits into the SCHIZONT. Trophozoites that are left over from cell division can go on to form gametocytes. Trophozoite

Related Publications

Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
June 2013, Antimicrobial agents and chemotherapy,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
June 1988, Annals of tropical medicine and parasitology,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
November 2006, Parasitology research,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
June 1963, Journal of pharmaceutical sciences,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
January 1965, Wiadomosci parazytologiczne,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
August 1979, Experimental parasitology,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
June 1973, Journal of medicinal chemistry,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
January 2016, The Journal of eukaryotic microbiology,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
September 2016, European journal of medicinal chemistry,
Ângela Sena-Lopes, and Raquel Nascimento das Neves, and Francisco Silvestre Brilhante Bezerra, and Mara Thais de Oliveira Silva, and Patrick C Nobre, and Gelson Perin, and Diego Alves, and Lucielli Savegnago, and Karine Rech Begnini, and Fabiana Kommling Seixas, and Tiago Collares, and Sibele Borsuk
January 1967, Acta biologica et medica Germanica,
Copied contents to your clipboard!