-transparent.png){kind=logo}
Antiparasitic activity of nine pyrazole derivatives against Trichomonas vaginalis, Entamoeba invadens and Plasmodium berghei. 1988
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
Department of Parasitology, Faculty of Pharmacy, Complutense University, Madrid, Spain.
Nine nitropyrazole derivatives were prepared and tested against Trichomonas vaginalis in vitro and in vivo, Entamoeba invadens in vitro and Plasmodium berghei in vivo. Three of the compounds, 4-4-nitropyrazole, 1-methyl-4-nitropyrazole and 4,4'-dinitro-1,1'-methylenedipyrazole, have an activity similar to that of metronidazole (used as the reference compound) against T. vaginalis and E. invadens after 48 hours of incubation. All the compounds tested were inactive against P. berghei.
Related Publications
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
March 2019,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
February 2020,
Parasites & vectors,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
July 2012,
Chemical biology & drug design,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
September 2016,
European journal of medicinal chemistry,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
September 2015,
Dalton transactions (Cambridge, England : 2003),
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
June 2013,
Antimicrobial agents and chemotherapy,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
November 2006,
Parasitology research,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
May 2017,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
March 2024,
Bioorganic & medicinal chemistry,
J A Escario, and
A M Igea, and
M Contreras, and
A R Martinez-Fernandez, and
R Claramunt, and
C Lopez
August 2014,
Parasitology research,
