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Intravenous injection of prostacyclin (100 micrograms/kg) in rats resulted in a decrease of systolic blood pressure within 2 minutes. Concentrations of cAMP in 15 brain regions and nuclei were determined by radioimmunoassay. In lower brain stem nuclei, such as the nucleus of the solitary tract and the lateral reticular nucleus (A1 and C1 catecholaminergic cell groups) cAMP levels were depleted significantly, while in others, including the locus coeruleus and the periaqueductal central gray, cAMP levels did not show any alterations. Levels of cAMP were also depleted in some of the hypothalamic nuclei (periventricular, anterior hypothalamic, ventromedial), and in cerebral cortical areas. Lowered cAMP levels in brain areas might indicate lower cellular activity in cells participating in baroreceptor control mechanisms.
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
January 1979,
Naunyn-Schmiedeberg's archives of pharmacology,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
December 1979,
Prostaglandins,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
February 1980,
Biochemical pharmacology,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
December 1978,
Cardiovascular research,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
June 1977,
Nature,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
January 1989,
Clinical and experimental hypertension. Part A, Theory and practice,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
January 1972,
Advances in cyclic nucleotide research,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
November 1991,
Journal of neurochemistry,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
October 1977,
Research communications in chemical pathology and pharmacology,
G Schmid, and
U Bahner, and
M Palkovits, and
H Geiger, and
A Heidland
January 1982,
Research communications in chemical pathology and pharmacology,
