Biomaterial Database

Ex utero intrapartum treatment (EXIT) for upper airway obstruction. 2017

Colin R Butler, and Elizabeth F Maughan, and Pranav Pandya, and Richard Hewitt

aDepartment of Otolaryngology, Great Ormond Street Hospital for Children NHS Foundation TrustbFetal Medicine Unit, University College London Hospital NHS Trust, London, UK.

OBJECTIVE Improvements in the antenatal diagnosis of congenital malformations have led to increased detection of fetal airway obstructing lesions, and pediatric ear, nose, and throat surgeons are increasingly involved in these cases. RESULTS This article outlines the typical range of pathology seen, the logistics in providing support for anticipated deliveries and the multidisciplinary management of complex airway cases. CONCLUSIONS Traditionally, difficulty in obtaining a patent airway at delivery was a major factor in the dismal prognosis of these pregnancies. The ex utero intrapartum treatment procedure, which involves controlled partial delivery of the fetus whilst maintaining placental circulation, allows various airway maneuvers to be performed to secure the airway in a controlled fashion.

UI	MeSH Term	Description	Entries
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011296	Prenatal Diagnosis	Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.	Diagnosis, Prenatal,Fetal Diagnosis,Fetal Imaging,Fetal Screening,Intrauterine Diagnosis,Antenatal Diagnosis,Antenatal Screening,Diagnosis, Antenatal,Diagnosis, Intrauterine,Prenatal Screening,Antenatal Diagnoses,Antenatal Screenings,Diagnosis, Fetal,Fetal Diagnoses,Fetal Imagings,Fetal Screenings,Imaging, Fetal,Intrauterine Diagnoses,Prenatal Diagnoses,Prenatal Screenings,Screening, Antenatal,Screening, Fetal,Screening, Prenatal
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260	Female		Females
D005315	Fetal Diseases	Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.	Embryopathies,Disease, Fetal,Diseases, Fetal,Embryopathy,Fetal Disease
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000402	Airway Obstruction	Any hindrance to the passage of air into and out of the lungs.	Choking,Airway Obstructions,Obstruction, Airway,Obstructions, Airway
D013513	Obstetric Surgical Procedures	Surgery performed on the pregnant woman for conditions associated with pregnancy, labor, or the puerperium. It does not include surgery of the newborn infant.	Obstetric Surgical Procedure,Obstetrical Surgery,Obstetrical Surgical Procedures,Procedure, Obstetric Surgical,Procedures, Obstetric Surgical,Surgery, Obstetric,Surgical Procedure, Obstetric,Surgical Procedures, Obstetric,Obstetric Surgeries,Obstetric Surgery,Obstetrical Surgeries,Obstetrical Surgical Procedure,Procedure, Obstetrical Surgical,Procedures, Obstetrical Surgical,Surgeries, Obstetric,Surgeries, Obstetrical,Surgery, Obstetrical,Surgical Procedure, Obstetrical,Surgical Procedures, Obstetrical
D036861	Delivery, Obstetric	Delivery of the FETUS and PLACENTA under the care of an obstetrician or a health worker. Obstetric deliveries may involve physical, psychological, medical, or surgical interventions.	Obstetric Delivery,Deliveries, Obstetric,Obstetric Deliveries