Biomaterial Database

Effects of antiallergic drugs on cyclic nucleotides in guinea pig ileum and trachea. 1987

R González, and M L Arruzazabala, and J Sarracent

Department of Pharmacology and Toxicology, National Center of Scientific Research, Havana, Cuba.

In former papers we have provided evidence on the protective effect of disodium cromoglycate (DSCG) and ketotifen (Ke) against the contractions induced by various agonists (histamine, serotonin, acetylcholine, prostaglandins) in ileal and tracheal smooth muscle of guinea pigs. To offer an insight into the mode of action of these antiallergic drugs we quantified concentrations of cyclic AMP and GMP in these tissues. We observed that DSCG (10(-3)-10(-2) M) significantly diminished the concentration of cyclic AMP in ileum and trachea of guinea pigs, but it increased the level of cyclic GMP in ileum. Ketotifen (10(-6)-10(-4) M) does not modify cAMP and cGMP in ileum, however, in trachea it significantly decreases the concentrations of cGMP. We also studied the effects of oxatomide, ICI 74.917 and BRL 10.833 on cyclic nucleotides concentrations in guinea pig ileum BRL 10.833 increases cAMP at a relatively high dose (10(-4) M). ICI 74.917 at the same dose decreases cGMP. Oxatomide (10(-6)-10(-4) M) does not modify concentrations of both nucleotides. Our results demonstrate that these antiallergic drugs do not have a unique effect on cyclic nucleotides. Our findings do not support a relevant role of these nucleotides on the mechanism of action of these antiallergic drugs.

UI	MeSH Term	Description	Entries
D007082	Ileum	The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D007189	Indans	Aryl CYCLOPENTANES that are a reduced (protonated) form of INDENES.	Indanones
D007665	Ketotifen	A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis.	4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one,Ketotifen Fumarate,Ketotifene,Ketotiphen,Ketotiphene,Zaditen,Fumarate, Ketotifen
D008297	Male		Males
D009712	Nucleotides, Cyclic		Cyclic Nucleotide,Cyclic Nucleotides,Nucleotide, Cyclic
D010618	Phenanthrolines		Phenanthroline
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D004205	Cromolyn Sodium	A chromone complex that acts by inhibiting the release of chemical mediators from sensitized MAST CELLS. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.	Disodium Cromoglycate,Sodium Cromoglycate,Aarane,Bicromat Spray,Cromoglicic Acid,Cromoglycate,Cromoglycic Acid,Cromolyn,FPL-670,Intal,Lomudal,Nalcrom,Nasalcrom,Opticrom,Vicrom,Acid, Cromoglicic,Acid, Cromoglycic,Cromoglycate, Disodium,Cromoglycate, Sodium,FPL 670,FPL670
D005260	Female		Females
D006152	Cyclic GMP	Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)	Guanosine Cyclic 3',5'-Monophosphate,Guanosine Cyclic 3,5 Monophosphate,Guanosine Cyclic Monophosphate,Guanosine Cyclic-3',5'-Monophosphate,3',5'-Monophosphate, Guanosine Cyclic,Cyclic 3',5'-Monophosphate, Guanosine,Cyclic Monophosphate, Guanosine,Cyclic-3',5'-Monophosphate, Guanosine,GMP, Cyclic,Guanosine Cyclic 3',5' Monophosphate,Monophosphate, Guanosine Cyclic