Biomaterial Database

Effects of the sesquiterpene capsidiol on isolated guinea-pig ileum and trachea, and on prostaglandin synthesis in vitro. 1993

A Nasiri, and A Holth, and L Björk

Department of Pharmacognosy, Biomedical Centre of Uppsala University, Sweden.

The sesquiterpene capsidiol, isolated from elicited, cultured cells of Nicotiana silvestris, inhibits contraction induced by the agonists, histamine, acetylcholine, bradykinin, and barium chloride in the isolated guinea-pig ileum. In addition, capsidiol inhibits contraction induced by histamine and carbachol in the isolated guinea-pig trachea in a nonspecific and noncompetitive but concentration-dependent manner. Capsidiol also inhibits prostaglandin synthesis (cyclooxygenase) in vitro in a concentration dependent manner.

UI	MeSH Term	Description	Entries
D007082	Ileum	The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D009126	Muscle Relaxation	That phase of a muscle twitch during which a muscle returns to a resting position.	Muscle Relaxations,Relaxation, Muscle,Relaxations, Muscle
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D010276	Parasympatholytics	Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.	Antispasmodic,Antispasmodic Agent,Antispasmodic Drug,Antispasmodics,Parasympathetic-Blocking Agent,Parasympathetic-Blocking Agents,Parasympatholytic,Parasympatholytic Agent,Parasympatholytic Drug,Spasmolytic,Spasmolytics,Antispasmodic Agents,Antispasmodic Drugs,Antispasmodic Effect,Antispasmodic Effects,Parasympatholytic Agents,Parasympatholytic Drugs,Parasympatholytic Effect,Parasympatholytic Effects,Agent, Antispasmodic,Agent, Parasympathetic-Blocking,Agent, Parasympatholytic,Agents, Antispasmodic,Agents, Parasympathetic-Blocking,Agents, Parasympatholytic,Drug, Antispasmodic,Drug, Parasympatholytic,Drugs, Antispasmodic,Drugs, Parasympatholytic,Effect, Antispasmodic,Effect, Parasympatholytic,Effects, Antispasmodic,Effects, Parasympatholytic,Parasympathetic Blocking Agent,Parasympathetic Blocking Agents
D010936	Plant Extracts	Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.	Herbal Medicines,Plant Extract,Extract, Plant,Extracts, Plant,Medicines, Herbal
D010947	Plants, Toxic	Plants or plant parts which are harmful to man or other animals.	Plants, Poisonous,Plant, Poisonous,Plant, Toxic,Poisonous Plant,Poisonous Plants,Toxic Plant,Toxic Plants
D011453	Prostaglandins	A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.	Prostaglandin,Prostanoid,Prostanoids
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000094162	Phytoalexins	Secondary metabolites produced and accumulated by plants infected with microbial pathogen or otherwise under abiotic stress. Phytoalexins are structurally diverse but in common play a role in triggering PLANT SYSTEMIC ACQUIRED RESISTANCE.	Diterpenoid Phytoalexins,Flavonoid Phytoalexins,Indole Phytoalexins,Isoflavonoid Phytoalexins,Phytoalexin Metabolites,Sesquiterpene Phytoalexins,Terpenoid Phytoalexins,Metabolites, Phytoalexin,Phytoalexins, Diterpenoid,Phytoalexins, Flavonoid,Phytoalexins, Indole,Phytoalexins, Isoflavonoid,Phytoalexins, Sesquiterpene,Phytoalexins, Terpenoid