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Sensitivity of Plasmodium falciparum to chloroquine, amodiaquine and mefloquine in Ibadan, Nigeria. 1988

O O Simooya, and A F Aderounmu, and L A Salako
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.

The schizontocidal effect of chloroquine was compared to that of amodiaquine in vivo and mefloquine in vitro. In the in-vivo study, 32 patients were randomly given chloroquine whilst 29 received amodiaquine. The mean parasite clearance time was 2.5 days for chloroquine and 2.4 days for amodiaquine. These times were not significantly different. The cure rate in both groups up to day 14 was 100%. In the in-vitro study, three isolates of Plasmodium falciparum were compared for their sensitivity to chloroquine and mefloquine. In all three isolates schizogony was inhibited at a concentration of 0.8 x 10(-6) mol/l of either drug. It was concluded that chloroquine is still an effective schizontocide and should remain the drug of choice for the treatment of P. falciparum in the Ibadan area.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008288 Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. Marsh Fever,Plasmodium Infections,Remittent Fever,Infections, Plasmodium,Paludism,Fever, Marsh,Fever, Remittent,Infection, Plasmodium,Plasmodium Infection
D008297 Male Males
D009549 Nigeria A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja. Federal Republic of Nigeria
D010963 Plasmodium falciparum A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics. Plasmodium falciparums,falciparums, Plasmodium
D011804 Quinolines
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D002738 Chloroquine The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. Aralen,Arechine,Arequin,Chingamin,Chlorochin,Chloroquine Sulfate,Chloroquine Sulphate,Khingamin,Nivaquine,Sulfate, Chloroquine,Sulphate, Chloroquine
D004351 Drug Resistance Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration. Resistance, Drug

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