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The inhibitory effect of insulin on Ca2+-current was supposed to be due to activation of phosphoproteinphosphotases stimulated by a specific intracellular insulin messenger. The results obtained support the above suggestion. Pretreatment of myocardial preparation with cycloheximide in low concentrations completely blocks the inhibitory insulin effect on Ca2+-current due, probably, to a decrease in peptide formation. Moreover, prolonged effect of the hormone involves a considerable increase of the current as compared to its initial value. Possible mechanisms of modifying effect of cycloheximide on the function of insulin-dependent regulatory system in the myocardium, are discussed.
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
August 1986,
Biokhimiia (Moscow, Russia),
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
January 1986,
Doklady Akademii nauk SSSR,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
May 1972,
The Medical annals of the District of Columbia,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
January 1984,
Society of General Physiologists series,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
December 1981,
Biochimica et biophysica acta,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
June 1973,
Journal of bacteriology,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
August 1982,
Circulation research,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
March 1983,
Circulation research,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
September 1997,
General physiology and biophysics,
O V Nakipova, and
Iu M Kokoz, and
A V Lazarev, and
A A Freĭdin, and
V A Krupenin
October 1978,
Biochemistry,
