BIOMAT Database Logo BIOMAT Database Logo

Cellular retinoic acid binding protein: detection and quantitation in regenerating axolotl limbs. 1988

A M McCormick, and H E Shubeita, and D L Stocum
Department of Biochemistry, University of Texas Health Science Center, Dallas 75235.

The concentrations of apo (unoccupied), holo (occupied), and total cellular retinoic acid binding protein (CRABP) were measured at various stages of axolotl limb regeneration. The ratio of apo-CRABP to holo-CRABP declined with advancing regenerate stage until the CRABP was all in the holo form. The increase in holo-CRABP is correlated with a stage-dependent shift in the effect of exogenous retinoic acid on regenerate pattern, from pattern duplication to inhibition of regeneration. The data suggest, though they do not prove, that these different morphological effects could be due to a shift from a CRABP-dependent to a CRABP-independent mechanism of exogenous retinoic acid (RA) action that is related to stage-specific variations in endogenous RA levels.

UI MeSH Term Description Entries
D012038 Regeneration The physiological renewal, repair, or replacement of tissue. Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D002352 Carrier Proteins Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D005121 Extremities The farthest or outermost projections of the body, such as the HAND and FOOT. Limbs,Extremity,Limb
D000557 Ambystoma A genus of the Ambystomatidae family. The best known species are the axolotl AMBYSTOMA MEXICANUM and the closely related tiger salamander Ambystoma tigrinum. They may retain gills and remain aquatic without developing all of the adult characteristics. However, under proper changes in the environment they metamorphose. Amblystoma,Ambystoma tigrinum,Tiger Salamander,Amblystomas,Ambystomas,Salamander, Tiger,Salamanders, Tiger,Tiger Salamanders
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014212 Tretinoin An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE). Retinoic Acid,Vitamin A Acid,Retin-A,Tretinoin Potassium Salt,Tretinoin Sodium Salt,Tretinoin Zinc Salt,Vesanoid,all-trans-Retinoic Acid,beta-all-trans-Retinoic Acid,trans-Retinoic Acid,Acid, Retinoic,Acid, Vitamin A,Acid, all-trans-Retinoic,Acid, beta-all-trans-Retinoic,Acid, trans-Retinoic,Potassium Salt, Tretinoin,Retin A,Salt, Tretinoin Potassium,Salt, Tretinoin Sodium,Salt, Tretinoin Zinc,Sodium Salt, Tretinoin,Zinc Salt, Tretinoin,all trans Retinoic Acid,beta all trans Retinoic Acid,trans Retinoic Acid
D018168 Receptors, Retinoic Acid Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized. Retinoic Acid Receptors,Retinoic Acid-Binding Proteins,Retinoic Acid Receptor,Proteins, Retinoic Acid-Binding,Receptor, Retinoic Acid,Retinoic Acid Binding Proteins

Related Publications

A M McCormick, and H E Shubeita, and D L Stocum
Cloning and Tissue Specific Expression of the Axolotl Cellular Retinoic Acid Binding Protein: (CRABP gene/Axolotl/Retinoic acid binding protein).
June 1993, Development, growth & differentiation,
A M McCormick, and H E Shubeita, and D L Stocum
Retinoic acid modifies positional memory in the anteroposterior axis of regenerating axolotl limbs.
March 1986, Developmental biology,
A M McCormick, and H E Shubeita, and D L Stocum
Morphogenetic effects of 9-cis-retinoic acid on the regenerating limbs of the axolotl.
January 1994, Roux's archives of developmental biology : the official organ of the EDBO,
A M McCormick, and H E Shubeita, and D L Stocum
Retinoic acid-induced change in anteroposterior positional identity in regenerating axolotl limbs is dose-dependent.
March 1992, Developmental dynamics : an official publication of the American Association of Anatomists,
A M McCormick, and H E Shubeita, and D L Stocum
Quantitation and tissue localization of the cellular retinoic acid-binding protein.
December 1987, Journal of cellular physiology,
A M McCormick, and H E Shubeita, and D L Stocum
The effect of retinoic acid on positional memory in the dorsoventral axis of regenerating axolotl limbs.
July 1990, Developmental biology,
A M McCormick, and H E Shubeita, and D L Stocum
Pitx1 expression in developing and regenerating axolotl limbs.
May 2008, Okajimas folia anatomica Japonica,
A M McCormick, and H E Shubeita, and D L Stocum
Retinoic acid-induced pattern duplication in regenerating urodele limbs.
June 1984, Developmental biology,
A M McCormick, and H E Shubeita, and D L Stocum
Cyclopamine induces digit loss in regenerating axolotl limbs.
July 2002, The Journal of experimental zoology,
A M McCormick, and H E Shubeita, and D L Stocum
Radioimmunoassays for retinol-binding protein, cellular retinol-binding protein, and cellular retinoic acid-binding protein.
January 1990, Methods in enzymology,
Copied contents to your clipboard!