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Administration of gamma-butyrolactone (GBL), an anesthetic which reduces dopaminergic neuronal activity, decreased the concentration of the dopamine (DA) metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the intermediate lobe of the pituitary gland, and increased alpha-melanocyte stimulating hormone (alpha MSH) concentrations in the serum of male rats. Bilateral electrical stimulation of the rostral arcuate nucleus, which contains perikarya of tuberohypophysial DA neurons, increased DOPAC concentrations in the intermediate lobe and decreased alpha MSH concentrations in the serum of GBL-anesthetized rats. Administration of the DA antagonist haloperidol prevented the decline in serum alpha MSH levels following arcuate nucleus stimulation, but had no effect on serum alpha MSH concentrations in sham-stimulated GBL-treated rats. These results indicate that GBL-induced decreases or stimulation-induced increases in the activity of tuberohypophysial DA neurons are accompanied by corresponding changes in the metabolism of DA in the intermediate lobe of the rat pituitary gland, and by reciprocal changes in the secretion of alpha MSH.
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
January 1991,
Neuroendocrinology,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
April 1990,
Neuroendocrinology,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
April 1993,
The Journal of pharmacology and experimental therapeutics,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
January 1991,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
December 1996,
The Journal of endocrinology,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
December 1991,
Neuroendocrinology,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
August 1990,
Neuroendocrinology,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
July 1990,
Neuroendocrinology,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
January 1994,
The Journal of pharmacology and experimental therapeutics,
S E Lindley, and
J W Gunnet, and
K J Lookingland, and
K E Moore
November 1992,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
