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The binding of the three dimeric forms of platelet-derived growth factor (PDGF), PDGF-AA, PDGF-AB and PDGF-BB, to human fibroblasts was studied. Cross-competition experiments revealed the existence of two different PDGF receptor classes: the type A PDGF receptor bound all three dimeric forms of PDGF, whereas the type B PDGF receptor bound PDGF-BB with high affinity and PDGF-AB with lower affinity, but not PDGF-AA. The sizes of the two receptors were estimated with affinity labeling techniques; the A type receptor appeared as a major component of 125 kd and a minor of 160 kd, and the B type receptor as two components of 160 and 175 kd. A previously established PDGF receptor monoclonal antibody, PDGFR-B2, was shown to react with the B type receptor only. The different abilities of the three dimeric forms of PDGF to stimulate incorporation of [3H]TdR into human fibroblasts indicated that the major mitogenic effect of PDGF is mediated via the B type receptor.
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
January 1990,
Growth factors (Chur, Switzerland),
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
December 1980,
The Journal of cell biology,
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
June 1988,
Science (New York, N.Y.),
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
August 1980,
Biochemical and biophysical research communications,
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
April 1995,
Journal of biochemical toxicology,
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
February 1993,
Journal of biochemistry,
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
February 1987,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
November 1978,
Biochimica et biophysica acta,
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
September 1990,
Biochimica et biophysica acta,
C H Heldin, and
G Bäckström, and
A Ostman, and
A Hammacher, and
L Rönnstrand, and
K Rubin, and
M Nistér, and
B Westermark
February 1994,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
