Biomaterial Database

Electrogenic Na+/HCO3- cotransport in neuroglia. 1988

M L Astion, and R K Orkand

Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, Old San Juan.

Membrane potential recording from glial cells in Necturus optic nerve in the presence of 2 mM Ba++, which was added to block the K+ conductance, gave the following results. 1) In HCO3- -free, low-Na+ solutions (11% of control; Na+ replaced with N-methyl-D-glucamine), the hyperpolarizing effect of adding 10 mM HCO3- was reduced by approximately 80%. 2) 4-acetamido-4'-isothiocyanato-stilbene-2,2'-disulfonic acid (SITS, 0.1 or 1 mM) reduced the effect of HCO3- by at least 50%. 3) In the presence of HCO3-, reduction of Na+ caused a depolarization which was much larger than that observed in nominally HCO3- -free solutions. These observations indicate the presence in the glial membrane of an electrogenic Na+/HCO3- cotransporter in which the stoichiometry of HCO3- to Na+ is greater than 1.

UI	MeSH Term	Description	Entries
D008564	Membrane Potentials	The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).	Resting Potentials,Transmembrane Potentials,Delta Psi,Resting Membrane Potential,Transmembrane Electrical Potential Difference,Transmembrane Potential Difference,Difference, Transmembrane Potential,Differences, Transmembrane Potential,Membrane Potential,Membrane Potential, Resting,Membrane Potentials, Resting,Potential Difference, Transmembrane,Potential Differences, Transmembrane,Potential, Membrane,Potential, Resting,Potential, Transmembrane,Potentials, Membrane,Potentials, Resting,Potentials, Transmembrane,Resting Membrane Potentials,Resting Potential,Transmembrane Potential,Transmembrane Potential Differences
D009337	Necturus	A genus of the Proteidae family with five recognized species, which inhabit the Atlantic and Gulf drainages.	Mudpuppy,Mudpuppies
D009457	Neuroglia	The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.	Bergmann Glia,Bergmann Glia Cells,Bergmann Glial Cells,Glia,Glia Cells,Satellite Glia,Satellite Glia Cells,Satellite Glial Cells,Glial Cells,Neuroglial Cells,Bergmann Glia Cell,Bergmann Glial Cell,Cell, Bergmann Glia,Cell, Bergmann Glial,Cell, Glia,Cell, Glial,Cell, Neuroglial,Cell, Satellite Glia,Cell, Satellite Glial,Glia Cell,Glia Cell, Bergmann,Glia Cell, Satellite,Glia, Bergmann,Glia, Satellite,Glial Cell,Glial Cell, Bergmann,Glial Cell, Satellite,Glias,Neuroglial Cell,Neuroglias,Satellite Glia Cell,Satellite Glial Cell,Satellite Glias
D002352	Carrier Proteins	Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes.	Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D004563	Electrochemistry	The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.	Electrochemistries
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001639	Bicarbonates	Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.	Bicarbonate,Bicarbonate Ions,Hydrogen Carbonates,Bicarbonate Ion,Carbonic Acid Ions,Hydrogen Carbonate,Carbonate, Hydrogen,Carbonates, Hydrogen,Ion, Bicarbonate,Ions, Bicarbonate,Ions, Carbonic Acid
D001693	Biological Transport, Active	The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.	Active Transport,Uphill Transport,Active Biological Transport,Biologic Transport, Active,Transport, Active Biological,Active Biologic Transport,Transport, Active,Transport, Active Biologic,Transport, Uphill
D012964	Sodium	A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.	Sodium Ion Level,Sodium-23,Ion Level, Sodium,Level, Sodium Ion,Sodium 23
D027982	Sodium-Bicarbonate Symporters	Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.	SLC4A5 Protein,Electrogenic Sodium Bicarbonate Cotransporter 1,Electrogenic Sodium Bicarbonate Cotransporter 4,Electroneutral Na(+)-Driven Cl-HCO3 Exchanger,Electroneutral Sodium Bicarbonate Exchanger 1,NBC1 Protein,NBC3 Protein,NBC4 Protein,NBCE1 Protein,NBCe2 Protein,NBCn2 Protein,NCBE Protein,Na-HCO3 Symport,SLC4A10 Protein,SLC4A4 Protein,SLC4A7 Protein,SLC4A8 Protein,Sodium Bicarbonate Cotransporter 2,Sodium Bicarbonate Cotransporter 3,Sodium Bicarbonate Symport,Sodium-Bicarbonate Cotransporter,Sodium-Coupled Bicarbonate Transporters,Sodium-driven chloride bicarbonate exchanger,Solute Carrier Family 4 Member 10,Solute Carrier Family 4 Member 4,Solute Carrier Family 4 Member 5,Solute Carrier Family 4 Member 7,Solute Carrier Family 4 Member 8,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 10,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 5,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 7,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 8,k-NBC3 Protein,Bicarbonate Symport, Sodium,Bicarbonate Transporters, Sodium-Coupled,Cotransporter, Sodium-Bicarbonate,Na HCO3 Symport,Protein, NBC1,Protein, NBC3,Protein, NBC4,Protein, NBCE1,Protein, NBCe2,Protein, NBCn2,Protein, SLC4A10,Protein, SLC4A4,Protein, SLC4A5,Protein, SLC4A7,Protein, SLC4A8,Protein, k-NBC3,Sodium Bicarbonate Cotransporter,Sodium Bicarbonate Symporters,Sodium Coupled Bicarbonate Transporters,Sodium driven chloride bicarbonate exchanger,Symport, Na-HCO3,Symport, Sodium Bicarbonate,Symporters, Sodium-Bicarbonate,Transporters, Sodium-Coupled Bicarbonate,k NBC3 Protein