Singlet oxygen-responsive micelles for enhanced photodynamic therapy. 2017

Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China.

Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffusion radius of singlet oxygen (1O2). We report a 1O2-responsive micellar nanoplatform subject to considerable size-expansion upon light triggering to facilitate on-demand release of photosensitizers. Imidazole, a well-known 1O2 scavenger, was incorporated in the hydrophobic core of amphiphilic copolymer micelles, and was used to coordinate with biocompatible Zn2+ and encapsulate the photosensitizer chlorin e6 (Ce6). The micelles are highly sensitive to light irradiation: 1O2 triggering induced dramatic particle size expansion due to the conversion of imidazole to hydrophilic urea, resulting in instantaneous release of Ce6 and rapid intracellular distribution. This 1O2-responsive, size-expandable nanosystem delivered substantially more Ce6 to tumor sites as compared to free Ce6, and exhibited improved anti-tumor efficacy in vivo in 4T1 tumor-bearing mice. This work opens new avenues of particle expansion-induced PDT enhancement by controlled imidazole chemistry.

UI MeSH Term Description Entries
D007093 Imidazoles Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008823 Micelles Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS. Micelle
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D010778 Photochemotherapy Therapy using oral or topical photosensitizing agents with subsequent exposure to light. Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D011166 Porphyrins A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin. Porphyrin
D002735 Chlorophyllides Products of the hydrolysis of chlorophylls in which the phytic acid side chain has been removed and the carboxylic acids saponified. Chlorophyllide
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D005260 Female Females

Related Publications

Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
June 2018, Nanotechnology,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
May 2018, ACS applied materials & interfaces,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
January 2024, International journal of nanomedicine,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
July 2020, Journal of materials chemistry. B,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
February 2019, Chemical science,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
August 2021, Biomaterials,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
May 2022, Chemical communications (Cambridge, England),
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
December 2018, Biomaterials science,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
February 2012, Proceedings of SPIE--the International Society for Optical Engineering,
Xiaodan Li, and Min Gao, and Keting Xin, and Ling Zhang, and Dan Ding, and Deling Kong, and Zheng Wang, and Yang Shi, and Fabian Kiessling, and Twan Lammers, and Jianjun Cheng, and Yanjun Zhao
March 2016, Chemical communications (Cambridge, England),
Copied contents to your clipboard!