Biomaterial Database

Virus dilution affects the anti-Rous sarcoma response of progressor but not regressor major histocompatibility (B) complex genotypes. 1988

S C Vincent, and R L Taylor

Department of Animal and Nutritional Sciences, University of New Hampshire, Durham 03824.

Responses to tumors induced by three dilutions of Rous sarcoma virus (RSV) were studied in UNH 105, a noninbred line of New Hampshire chickens. Single-male matings produced progeny of three B genotypes: B23/B23 (tumor regressor) and B23/B24 and B24/B24 (tumor progressors). A total of 223 6-wk-old chicks were wingweb inoculated with one of three dilutions (10(-3), 4 X 10(-3), and 10(-4)) of a pseudotype of Bryan high titer RSV designated as BH RSV (RAV-1). A tumor profile index (TPI), an indicator of antitumor response, was assigned to each chick based on six postinoculation tumor size scores. Incidence of mortality was itemized for B genotypes at each virus dilution and the number of days to death (DTD) was recorded for 44 chicks with terminal tumors. Analysis of mean TPI revealed a virus dilution X B genotype interaction, with significant differences among B24/B24 chickens at a 10(-3) virus dilution (TPI 3.1), a 4 X 10(-3) virus dilution (TPI 2.6), and all other subclasses (TPI 1.8 or less). Both virus dilution and B genotype affected the incidence of mortality as shown by chi-square analysis. These data demonstrate that virus dilution influenced the antitumor response in progressor but not in regressor B complex genotypes.

UI	MeSH Term	Description	Entries
D008285	Major Histocompatibility Complex	The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.	Histocompatibility Complex,Complex, Histocompatibility,Complex, Major Histocompatibility,Complices, Histocompatibility,Complices, Major Histocompatibility,Histocompatibility Complex, Major,Histocompatibility Complices,Histocompatibility Complices, Major,Major Histocompatibility Complices
D008297	Male		Males
D011201	Poultry Diseases	Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	Disease, Poultry,Diseases, Poultry,Poultry Disease
D002645	Chickens	Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.	Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005260	Female		Females
D005838	Genotype	The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.	Genogroup,Genogroups,Genotypes
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001357	Sarcoma, Avian	Connective tissue tumors, affecting primarily fowl, that are usually caused by avian sarcoma viruses.	Avian Sarcoma,Rous Sarcoma,Sarcoma, Rous,Avian Sarcomas,Sarcomas, Avian