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The influence of B genotype on the formation of a second RSV-induced tumor was studied. Line 6(3) (B2/B2) and (6(1) x 15(1))F3 and F4 B2/B2 and B5/B5 chickens were challenged with RSV in the left wingweb at 6 weeks of age. Tumor-bearing animals then were rechallenged with RSV in the right wingweb at either 10, 11, or 12 days post primary inoculation. Most B2/B2 hosts resisted development of a second tumor compared to none of the B5/B5 hosts. Failure of a second tumor to develop in B2/B2 hosts was not explained by humoral neutralization of RSV in vivo, since sera from 83% of B2/B2 and 100% of B5/B5 tumor bearing chickens failed to neutralize virus prior to 12 days post primary inoculation. Humoral antiviral immunity appeared later in B5/B5 than in B2/B2 hosts. Humoral antiviral immunity appears to play little if any role in resistance to early RSV-induced tumor development, but likely both humoral and cell-mediated antitumor immunity do.
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
October 1989,
Avian pathology : journal of the W.V.P.A,
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
November 1988,
Poultry science,
P M Guyre, and
R M Zsigray, and
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W R Dunlop
September 1986,
Poultry science,
P M Guyre, and
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W M Collins, and
W R Dunlop
January 1988,
Animal genetics,
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
June 1994,
Poultry science,
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
August 2009,
Poultry science,
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
April 2010,
Poultry science,
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
January 1992,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
October 1981,
Poultry science,
P M Guyre, and
R M Zsigray, and
W M Collins, and
W R Dunlop
February 1989,
Poultry science,
