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Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, accounting for 10% of European patients on renal replacement therapy. In the previous years, many approaches to slow the progression of ADPKD were studied and many clinical trials published. In addition to having diagnostic role, the description of the genotype is even important to predict the progression of the disease and contributes, combined with several other factors, to a more precise patients classification. With the availability of disease-modifying drugs, "fast progression factors" are needed to early recognize those patients who would likely progress, before cyst growth reaches a critical value. ERA-EDTA working group on inherited kidney disorders included a series of recommendations resulting in a hierarchical decision algorithm to select patients who are most likely to benefit from the treatment. Beyond diagnosis, we will also discuss the important role of genetics in ADPKD progression and management.
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
October 2003,
Clinical and investigative medicine. Medecine clinique et experimentale,
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
January 2011,
Nephron. Clinical practice,
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
October 2011,
Biochimica et biophysica acta,
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
February 2003,
The Journal of laboratory and clinical medicine,
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
November 2014,
Journal of the American Society of Nephrology : JASN,
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
August 2012,
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Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
October 2001,
Lancet (London, England),
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
June 1989,
Seminars in nephrology,
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
January 2000,
Molecular genetics and metabolism,
Valentina Corradi, and
Anna Giuliani, and
Fiorella Gastaldon, and
Massimo de Cal, and
Barbara Mancini, and
Anna Montaldi, and
Alberta Alghisi, and
Irene Capelli, and
Gaetano La Manna, and
Claudio Ronco
August 2000,
Human genetics,
