BIOMAT Database Logo BIOMAT Database Logo

Post-occlusive reactive hyperaemia of skin microvasculature and foot complications in type 2 diabetes. 2017

Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
School of Health Sciences, University of Newcastle, Australia. Electronic address: Sean.Lanting@newcastle.edu.au.

OBJECTIVE Diabetes-related microvascular disease has been implicated in the development of foot ulceration and amputation. Assessment of microvascular function may be effective in identifying those at risk of diabetic foot complications. We investigated the relationship between active or previous foot complication and post-occlusive reactive hyperaemia (PORH) measured by laser-Doppler fluxmetry (LDF) in people with type 2 diabetes. METHODS PORH measures were obtained from the hallux apex in 105 people with type 2 diabetes. Associations were investigated between active or previous foot complication and PORH measures: time to peak (TtPeak) and peak as a percentage of baseline (P%BL). Multinomial logistic regression was used to determine the association of PORH with the likelihood of active foot ulcer or previous foot complication. RESULTS For each second increase in TtPeak, the likelihood of a participant having a history of foot complication is increased by 2% (OR=1.019, p=0.01). This association was not reflected in people with an active foot ulcer (OR=1.003, p=0.832). P%BL was not found to be significantly different between those with a current or previous foot complication and those without (p=0.404). CONCLUSIONS This investigation in a cohort with type 2 diabetes has demonstrated that longer TtPeak is associated with history of diabetic foot complications.

UI MeSH Term Description Entries
D008297 Male Males
D008833 Microcirculation The circulation of the BLOOD through the MICROVASCULAR NETWORK. Microvascular Blood Flow,Microvascular Circulation,Blood Flow, Microvascular,Circulation, Microvascular,Flow, Microvascular Blood,Microvascular Blood Flows,Microvascular Circulations
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009517 New South Wales A state in southeastern Australia. Its capital is Sydney. It was discovered by Captain Cook in 1770 and first settled at Botany Bay by marines and convicts in 1788. It was named by Captain Cook who thought its coastline resembled that of South Wales. (From Webster's New Geographical Dictionary, 1988, p840 & Room, Brewer's Dictionary of Names, 1992, p377)
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D003925 Diabetic Angiopathies VASCULAR DISEASES that are associated with DIABETES MELLITUS. Diabetic Vascular Complications,Diabetic Vascular Diseases,Microangiopathy, Diabetic,Angiopathies, Diabetic,Angiopathy, Diabetic,Diabetic Angiopathy,Diabetic Microangiopathies,Diabetic Microangiopathy,Diabetic Vascular Complication,Diabetic Vascular Disease,Microangiopathies, Diabetic,Vascular Complication, Diabetic,Vascular Complications, Diabetic,Vascular Disease, Diabetic,Vascular Diseases, Diabetic
D003929 Diabetic Neuropathies Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325) Diabetic Amyotrophy,Diabetic Autonomic Neuropathy,Diabetic Neuralgia,Diabetic Polyneuropathy,Neuralgia, Diabetic,Asymmetric Diabetic Proximal Motor Neuropathy,Diabetic Asymmetric Polyneuropathy,Diabetic Mononeuropathy,Diabetic Mononeuropathy Simplex,Diabetic Neuropathy, Painful,Mononeuropathy, Diabetic,Symmetric Diabetic Proximal Motor Neuropathy,Amyotrophies, Diabetic,Amyotrophy, Diabetic,Asymmetric Polyneuropathies, Diabetic,Asymmetric Polyneuropathy, Diabetic,Autonomic Neuropathies, Diabetic,Autonomic Neuropathy, Diabetic,Diabetic Amyotrophies,Diabetic Asymmetric Polyneuropathies,Diabetic Autonomic Neuropathies,Diabetic Mononeuropathies,Diabetic Mononeuropathy Simplices,Diabetic Neuralgias,Diabetic Neuropathies, Painful,Diabetic Neuropathy,Diabetic Polyneuropathies,Mononeuropathies, Diabetic,Mononeuropathy Simplex, Diabetic,Mononeuropathy Simplices, Diabetic,Neuralgias, Diabetic,Neuropathies, Diabetic,Neuropathies, Diabetic Autonomic,Neuropathies, Painful Diabetic,Neuropathy, Diabetic,Neuropathy, Diabetic Autonomic,Neuropathy, Painful Diabetic,Painful Diabetic Neuropathies,Painful Diabetic Neuropathy,Polyneuropathies, Diabetic,Polyneuropathies, Diabetic Asymmetric,Polyneuropathy, Diabetic,Polyneuropathy, Diabetic Asymmetric,Simplex, Diabetic Mononeuropathy,Simplices, Diabetic Mononeuropathy
D005260 Female Females
D006214 Hallux The innermost digit of the foot in PRIMATES. Big Toe,Great Toe,Big Toes,Great Toes,Toe, Big,Toe, Great,Toes, Big,Toes, Great

Related Publications

Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Type 2 diabetes impairs vascular responsiveness to nitric oxide, but not the venoarteriolar reflex or post-occlusive reactive hyperaemia in forearm skin.
December 2021, Experimental dermatology,
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Aspirin, prostacyclin and post-occlusive reactive hyperaemia in man.
October 1982, Prostaglandins, leukotrienes, and medicine,
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
The effect of oxygen supplementation on post-occlusive reactive hyperaemia in human forearm skin.
February 1991, International journal of microcirculation, clinical and experimental,
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Post-occlusive reactive hyperaemia in the heart, skeletal muscle and skin of control and capsaicin-pre-treated pigs.
October 1989, Acta physiologica Scandinavica,
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Relationship between post-occlusive forearm skin reactive hyperaemia and vascular disease in patients with Type 2 diabetes--a novel index for detecting micro- and macrovascular dysfunction using laser Doppler flowmetry.
January 2009, Diabetic medicine : a journal of the British Diabetic Association,
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Determinants of post-ischaemic reactive hyperaemia in patients with diabetes mellitus type II.
September 1999, Clinical physiology (Oxford, England),
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Nailfold capillaroscopy in non-insulin dependent diabetes mellitus: blood flow velocity during rest and post-occlusive reactive hyperaemia.
September 1990, Clinical physiology (Oxford, England),
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Skin perfusion patterns (fluorescein perfusography) during reactive hyperaemia in peripheral arterial occlusive disease.
November 1991, Clinical physiology (Oxford, England),
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Reactive hyperaemia augments local heat-induced skin hyperaemia.
April 2022, Experimental physiology,
Sean M Lanting, and Alex L Barwick, and Stephen M Twigg, and Nathan A Johnson, and Michael K Baker, and Simon K Chiu, and Ian D Caterson, and Vivienne H Chuter
Diabetes foot complications and standardized mortality rate in type 2 diabetes.
December 2023, Diabetes, obesity & metabolism,
Copied contents to your clipboard!