Biomaterial Database

The effect of oxygen supplementation on post-occlusive reactive hyperaemia in human forearm skin. 1991

F Khan, and F M Carnochan, and N C Abbot, and S B Wilson

Vascular Laboratory, Ninewells Hospital and Medical School, Dundee, Scotland.

The effects of raised tissue oxygen levels on reactive hyperaemia (RH) in the skin following arterial occlusion of short duration were investigated. Oxygen levels were increased by breathing 100% oxygen at 1 and 2 atmospheres absolute (ATA) in a hyperbaric chamber. Superficial skin blood flow and oxygen tension were measured throughout using a laser Doppler flowmeter and a transcutaneous oxygen monitor. The basal pre-occlusion and the maximum post-occlusion blood flows (Flb and Flmax), the time taken for flow to fall to half maximum (TR1/2), and the time for flow to return to its basal level (TR) were measured. Pre- and end-occlusion transcutaneous oxygen levels were also recorded. Oxygen breathing at 1 ATA significantly reduced TR1/2 (p less than 0.05) and at 2 ATA significantly reduced TR1/2 and TR (p less than 0.005 and p less than 0.0001) compared with control measurements during air breathing at 1 ATA. Flmax was not significantly reduced breathing oxygen at 1 or 2 ATA. These findings support the view that maximum post-occlusion blood flow in superficial skin is determined mainly by myogenic mechanisms, whereas the recovery of blood flow to basal levels is influenced largely by oxygen tension. We conclude that the direct vasoconstrictor effect of high oxygen levels is small and that the faster recovery at high tissue oxygen tensions may result from a decrease in vasodilators formed during hypoxia.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D001783	Blood Flow Velocity	A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.	Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D001785	Blood Gas Monitoring, Transcutaneous	The noninvasive measurement or determination of the partial pressure (tension) of oxygen and/or carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable of picking up the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin.	Carbon Dioxide Partial Pressure Determination, Transcutaneous,Cutaneous Oximetry,Oximetry, Transcutaneous,Oxygen Partial Pressure Determination, Transcutaneous,Transcutaneous Blood Gas Monitoring,Transcutaneous Capnometry,Transcutaneous Oximetry,PtcO2,TcPCO2,Capnometries, Transcutaneous,Capnometry, Transcutaneous,Cutaneous Oximetries,Oximetries, Cutaneous,Oximetries, Transcutaneous,Oximetry, Cutaneous,Transcutaneous Capnometries,Transcutaneous Oximetries
D003250	Constriction	The act of constricting.	Clamping,Clampings,Constrictions
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006931	Hyperbaric Oxygenation	The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.	Oxygenation, Hyperbaric,Hyperbaric Oxygen Therapy,Hyperbaric Oxygen Therapies,Hyperbaric Oxygenations,Oxygen Therapies, Hyperbaric,Oxygen Therapy, Hyperbaric,Oxygenations, Hyperbaric,Therapies, Hyperbaric Oxygen,Therapy, Hyperbaric Oxygen
D006940	Hyperemia	The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).	Active Hyperemia,Arterial Hyperemia,Passive Hyperemia,Reactive Hyperemia,Venous Congestion,Venous Engorgement,Congestion, Venous,Engorgement, Venous,Hyperemia, Active,Hyperemia, Arterial,Hyperemia, Passive,Hyperemia, Reactive,Hyperemias,Hyperemias, Reactive,Reactive Hyperemias