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2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture. 2017
Shaoman Zhou, and
Sawsan Mahmoud, and
Peng Liu, and
Longhu Zhou, and
Maryam Ehteshami, and
Leda Bassit, and
Sijia Tao, and
Robert A Domaoal, and
Ozkan Sari, and
Coralie De Schutter, and
Sheida Amiralaei, and
Ahmed Khalil, and
Olivia Ollinger Russell, and
Tamara McBrayer, and
Tony Whitaker, and
Nageh Abou-Taleb, and
Franck Amblard, and
Steven J Coats, and
Raymond F Schinazi
Center for AIDS Research, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine , Atlanta, Georgia 30307, United States.
Pan-genotypic nucleoside HCV inhibitors display a high genetic barrier to drug resistance and are the preferred direct-acting agents to achieve complete sustained virologic response in humans. Herein, we report, the discovery of a β-d-2'-Cl,2'-F-uridine phosphoramidate nucleotide 16, as a nontoxic pan-genotypic anti-HCV agent. Phosphoramidate 16 in its 5'-triphosphate form specifically inhibited HCV NS5B polymerase with no marked inhibition of human polymerases and cellular mitochondrial RNA polymerase. Studies on the intracellular half-life of phosphoramidate 16-TP in live cells demonstrated favorable half-life of 11.6 h, suggesting once-a-day dosing. Stability in human blood and favorable metabolism in human intestinal microsomes and liver microsomes make phosphoramidate 16 a prospective candidate for further studies to establish its potential value as a new anti-HCV agent.
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