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Fifteen haemophiliac patients acquired antibodies to human T-lymphotropic virus type III during 1984. One batch of factor VIII concentrate given to all these patients is presumed to be the cause of the seroconversion. A further eighteen patients who received the same batch did not seroconvert and one other patient became seropositive but had not received this batch. Before transfusion of the implicated batch the patients had low T-helper-cell numbers and T-helper/suppressor ratios; neither changed in those who seroconverted. The probability of seroconversion was independently related to the pre-existing low T-helper/suppressor ratio, the number of vials of the implicated batch transfused, and the total annual factor VIII consumption. Ten other patients received a batch of factor IX concentrate from the same donor plasma; none of these patients seroconverted.
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
January 1987,
Hematologic pathology,
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
June 1986,
MMWR. Morbidity and mortality weekly report,
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
August 1985,
Science (New York, N.Y.),
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
July 1985,
Science (New York, N.Y.),
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
July 1986,
Journal of immunology (Baltimore, Md. : 1950),
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
September 1985,
Blood,
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
August 1986,
JAMA,
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
June 1985,
Lancet (London, England),
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
December 1985,
Annals of internal medicine,
C A Ludlam, and
J Tucker, and
C M Steel, and
R S Tedder, and
R Cheingsong-Popov, and
R A Weiss, and
D B McClelland, and
I Philp, and
R J Prescott
July 1986,
American journal of diseases of children (1960),
