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The human T-lymphotropic virus type III (HTLV-III) is the primary cause of the acquired immunodeficiency syndrome (AIDS) and related disorders (ARC). Prior studies have reported that nearly all symptomatic patients with AIDS or ARC manifest antibody to HTLV-III. This observation has engendered efforts to screen for HTLV-III, especially prior to blood donation, with assays for antibody to HTLV-III. We report the first two cases, one with AIDS and one with ARC, that are HTLV-III virus positive but antibody negative. Accurate diagnosis of HTLV-III infection in some cases may require direct virus culture or tests for antigen. In addition, lack of HTLV-III antibody may indicate an atypical clinical course of AIDS.
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P I Hartzband, and
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M G Sarngadharan, and
M F McLane, and
M Essex, and
R Gallo
January 1987,
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J E Groopman, and
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L Shulman, and
S Z Salahuddin, and
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R Gallo
August 1985,
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J E Groopman, and
P I Hartzband, and
L Shulman, and
S Z Salahuddin, and
M G Sarngadharan, and
M F McLane, and
M Essex, and
R Gallo
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J E Groopman, and
P I Hartzband, and
L Shulman, and
S Z Salahuddin, and
M G Sarngadharan, and
M F McLane, and
M Essex, and
R Gallo
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J E Groopman, and
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M G Sarngadharan, and
M F McLane, and
M Essex, and
R Gallo
August 1985,
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J E Groopman, and
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M G Sarngadharan, and
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M Essex, and
R Gallo
May 1992,
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M F McLane, and
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R Gallo
November 1985,
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J E Groopman, and
P I Hartzband, and
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S Z Salahuddin, and
M G Sarngadharan, and
M F McLane, and
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R Gallo
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