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Food intake of rhesus monkeys was limited to a single daily 2 hr session of banana flavored pellet availability, seven days a week. Following stabilization of intake, the effects of intragastric bromazepam, diazepam and pentobarbital, when given alone, were determined by delivering a dose twice weekly, 60 min before the session. Dose-dependent increases in food intake were observed with the following descending order of potencies: bromazepam, diazepam and pentobarbital. RO 15-1788 (0.5-1.0 mg/kg, IM), when given alone, five min before the session had no effect on food intake. When given in combination with bromazepam and diazepam, RO 15-1788 completely blocked the increases in food intake observed when the benzodiazepines were given alone. The specificity of this antagonism was shown by the failure of RO 15-1788 to alter the food intake increases induced by pentobarbital. These results confirm and extend previous reports of the specific antagonism of benzodiazepine behavioral effects by RO 15-1788 to an additional species and another behavioral effect of benzodiazepines.
R W Foltin, and
S Ellis, and
C R Schuster
August 1988,
Der Anaesthesist,
R W Foltin, and
S Ellis, and
C R Schuster
November 1981,
Lancet (London, England),
R W Foltin, and
S Ellis, and
C R Schuster
January 1987,
Journal de toxicologie clinique et experimentale,
R W Foltin, and
S Ellis, and
C R Schuster
December 1986,
Anaesthesia,
R W Foltin, and
S Ellis, and
C R Schuster
July 1981,
Naunyn-Schmiedeberg's archives of pharmacology,
R W Foltin, and
S Ellis, and
C R Schuster
January 1985,
Psychopharmacology,
R W Foltin, and
S Ellis, and
C R Schuster
March 1983,
Molecular pharmacology,
R W Foltin, and
S Ellis, and
C R Schuster
May 1987,
Wiener medizinische Wochenschrift (1946),
R W Foltin, and
S Ellis, and
C R Schuster
April 1987,
Brain research,
R W Foltin, and
S Ellis, and
C R Schuster
October 1984,
British journal of clinical pharmacology,
