Biomaterial Database

[The effect of antral branch on canine antral gastrin and somatostatin concentrations in gastric vagotomy]. 1985

M Tsutsui

Three types of vagotomy: selective proximal gastric vagotomy with (SPV + P) or without (SPV) pyloroplasty and selective gastric vagotomy with pyloroplasty (SV + P) were performed on mongrel dogs, and antral immunoreactive gastrin (IRG) concentration and somatostatin like immunoreactivity (SLI) concentration were measured before and after operations. In both SPV and SPV + P groups, significant (p less than 0.01) increase in IRG concentration at the 8th and 12th postoperative weeks were observed. IRG concentration at the 12th postoperative week was significantly high (p less than 0.01) in SPV + P group compared with that in SPV group. In SV + P group, no significant change in IRG concentration was observed up to the 12th postoperative week, however, after 6th postoperative month a significant (p less than 0.01) increase was observed. SLI concentration showed no significant increase in both SPV and SV + P groups. In SPV + P group, it showed a significant (p less than 0.05) increase at the 12th postoperative week, when IRG concentration was remarkably high compared with that in the other groups. Furthermore, a significant (p less than 0.01) correlation was observed between pre- and post-operative IRG concentrations and SLI concentrations in SPV and SPV + P groups. The above results suggested that the antral branch influenced the increase in antral IRG concentration early after vagotomy and that the IRG increase might affect the increase in SLI concentration.

UI	MeSH Term	Description	Entries
D011706	Pyloric Antrum	The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS).	Antrum, Pyloric,Gastric Antrum,Antrum, Gastric,Antrums, Gastric,Antrums, Pyloric,Gastric Antrums,Pyloric Antrums
D011863	Radioimmunoassay	Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.	Radioimmunoassays
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005753	Gastric Mucosa	Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.	Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D005755	Gastrins	A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.	Gastrin
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013004	Somatostatin	A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.	Cyclic Somatostatin,Somatostatin-14,Somatotropin Release-Inhibiting Hormone,SRIH-14,Somatofalk,Somatostatin, Cyclic,Somatotropin Release-Inhibiting Factor,Stilamin,Somatostatin 14,Somatotropin Release Inhibiting Factor,Somatotropin Release Inhibiting Hormone
D014629	Vagotomy, Proximal Gastric	Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. Since the procedure leaves the vagal branches to the antrum and PYLORUS intact, it circumvents gastric drainage required with truncal vagotomy techniques.	Vagotomy, Highly Selective,Vagotomy, Parietal Cell,Vagotomy, Selective Proximal,Gastric Vagotomies, Proximal,Gastric Vagotomy, Proximal,Highly Selective Vagotomies,Highly Selective Vagotomy,Parietal Cell Vagotomies,Parietal Cell Vagotomy,Proximal Gastric Vagotomies,Proximal Gastric Vagotomy,Proximal Vagotomies, Selective,Proximal Vagotomy, Selective,Selective Proximal Vagotomies,Selective Proximal Vagotomy,Selective Vagotomies, Highly,Vagotomies, Highly Selective,Vagotomies, Parietal Cell,Vagotomies, Proximal Gastric,Vagotomies, Selective Proximal