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As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subjects. In non-ulcer subjects, including normal subjects and patients with atrophic gastritis, antral somatostatin concentrations were correlated inversely with the degree of antral gastritis, while in the patients with peptic ulcer, especially in duodenal ulcer, they were low, irrespective of histological picture of antral mucosa. In the patients with duodenal ulcer, low antral somatostatin concentrations with high antral gastrin/somatostatin ratio may cause increased serum gastrin levels and increased gastric acid secretion. From the above findings, it has been concluded that low antral somatostatin levels may be related to the pathogenesis of duodenal ulcer disease.
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
January 1986,
Virchows Archiv. A, Pathological anatomy and histopathology,
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
March 1980,
Annals of surgery,
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
April 1974,
Lancet (London, England),
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
July 1982,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
June 1974,
Lancet (London, England),
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
June 1974,
Lancet (London, England),
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
May 1974,
Lancet (London, England),
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
June 1974,
Lancet (London, England),
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
June 1986,
Gut,
K Sumii, and
T Fukushima, and
K Hirata, and
Y Matsumoto, and
E Sanuki, and
S Tsumaru, and
M Sumioka, and
A Miyoshi, and
Y Miyachi
January 1993,
The Korean journal of internal medicine,
