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Interactions between phenylephrine-induced oxygen consumption, lactate and pyruvate output, and urea and glucose production were examined in perfused livers from fed or 48-h-fasted rats. Within 2 min of phenylephrine infusion, oxygen consumption in perfused livers was increased by approximately 40%. Increases in oxygen consumption induced by phenylephrine were essentially abolished in the presence of carboxyatractyloside, whereas those induced by dinitrophenol were still evident. Phenylephrine-induced increases in oxygen consumption were accompanied by enhanced rates of gluconeogenesis and ureogenesis in livers from fed or 48-h-fasted animals. These data indicate that phenylephrine-induced increases in respiration in perfused rat liver may result from an enhanced rate of mitochondrial oxidative phosphorylation in response to an increased cellular energy requirement.
W M Taylor, and
E Van de Pol, and
F L Bygrave
June 1983,
The Biochemical journal,
W M Taylor, and
E Van de Pol, and
F L Bygrave
February 1982,
The Journal of biological chemistry,
W M Taylor, and
E Van de Pol, and
F L Bygrave
March 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
W M Taylor, and
E Van de Pol, and
F L Bygrave
December 1982,
The Biochemical journal,
W M Taylor, and
E Van de Pol, and
F L Bygrave
May 1984,
The Biochemical journal,
W M Taylor, and
E Van de Pol, and
F L Bygrave
March 1989,
FEBS letters,
W M Taylor, and
E Van de Pol, and
F L Bygrave
November 1982,
European journal of biochemistry,
W M Taylor, and
E Van de Pol, and
F L Bygrave
December 1982,
The Journal of biological chemistry,
W M Taylor, and
E Van de Pol, and
F L Bygrave
March 1983,
The Biochemical journal,
W M Taylor, and
E Van de Pol, and
F L Bygrave
October 1987,
Japanese journal of pharmacology,
