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An insulin suppression test performed in random order with either biosynthetic human insulin or purified pork insulin was used to compare biological activity of these two insulins in obese patients suffering from varying degrees of glucose intolerance. Blood glucose curve, steady-state blood glucose levels, insulin sensitivity indices and steady-state plasma insulin levels were identical during the two sets of tests. Furthermore endogenous insulin and glucagon secretion were similarly suppressed. The insulin suppression test is a simple and rapid procedure to compare the biological activity of fast-acting insulins. Our results confirm the insulin-resistance in obesity and clearly show that biosynthetic human and porcine insulins have similar biological potency.
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
January 1981,
Diabetes care,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
July 1985,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
May 1983,
MMW, Munchener medizinische Wochenschrift,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
January 1981,
Diabetes care,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
January 1981,
Diabetes care,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
June 1983,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
January 1981,
Diabetes care,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
January 1981,
Diabetes care,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
January 1982,
Diabetes care,
J L Richard, and
M Rodier, and
G Cavalie, and
H Lachkar, and
A Orsetti, and
L Monnier, and
J Mirouze
January 1981,
Diabetes care,
