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The possible pancreatic origin of intestinal kallikrein was studied in a jejuno-ileal bypass model in the rat. The bypassed loops were made of variable lengths (2-72 cm) and samples were taken at 10 cm intervals to relate enzyme activities to adaptive changes caused by local and systemic stimulus. The kallikrein activity was dramatically reduced (mean 92.3%) in the bypassed loops while only moderately reduced (mean 35.8%) activities were found in the intestine remaining in continuity. Kallikrein was uniformly distributed throughout the functional small intestine in normal and bypass operated animals. The longitudinal distribution profiles obtained for brush border enzymes in normal animals were almost absent in the bypassed loops, but were apparent in the remaining intestine. The main adaptive growth was observed in the remaining small intestine, Both here and in the loop, the growth depended on the amount of bypassed tissue. Our observations are strongly in favour of a pancreatic origin of the glandular kallikrein activity found in the small intestine in the rat.
D W Skagen, and
K J Andersen
August 1992,
Journal of nutritional science and vitaminology,
D W Skagen, and
K J Andersen
March 1990,
Gut,
D W Skagen, and
K J Andersen
February 1989,
Transplantation proceedings,
D W Skagen, and
K J Andersen
February 1963,
Biulleten' eksperimental'noi biologii i meditsiny,
D W Skagen, and
K J Andersen
January 1976,
The Mount Sinai journal of medicine, New York,
D W Skagen, and
K J Andersen
February 1989,
Gastroenterology,
D W Skagen, and
K J Andersen
October 1998,
Neurogastroenterology and motility,
D W Skagen, and
K J Andersen
December 1989,
Digestive diseases and sciences,
D W Skagen, and
K J Andersen
August 1997,
Biopharmaceutics & drug disposition,
D W Skagen, and
K J Andersen
January 1979,
Advances in experimental medicine and biology,
