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The number of G cells and D cells per area unit and the G cell/D cell ratio was studied in control subjects and patients with duodenal or gastric ulcer. A great inter-individual variation in the population density of both types of cells was observed in the three groups studied. G cell density was significantly decreased in both duodenal and gastric ulcer patients, when compared with controls; whereas no difference in G cell density was seen between duodenal ulcer patients and gastric ulcer patients. However, D cell density was significantly decreased in duodenal ulcer patients when compared with control subjects and gastric ulcer patients. In this latter group, D cell density was also lower than in control subjects. A significant positive linear correlation between G cell number and D cell number was found in the three groups studied. The G cell/D cell ratio was significantly increased in duodenal and gastric ulcer patients when compared with controls. This was mainly due to a decrease in D cell numbers. It is concluded that a local deficit in antral D cells in patients with peptic ulcer may favor the pathogenesis of ulcer disease.
A J Torres, and
L Ortega, and
J Blanco, and
R Fernandez-Durango, and
F Hernandez, and
A Suarez, and
R Cuberes, and
J Sanz, and
J L Balibrea
January 1981,
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April 1982,
Gut,
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A Suarez, and
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J Sanz, and
J L Balibrea
April 2002,
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F Hernandez, and
A Suarez, and
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April 1986,
Zhonghua nei ke za zhi,
A J Torres, and
L Ortega, and
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A Suarez, and
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J L Balibrea
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A J Torres, and
L Ortega, and
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June 1974,
Lancet (London, England),
A J Torres, and
L Ortega, and
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R Fernandez-Durango, and
F Hernandez, and
A Suarez, and
R Cuberes, and
J Sanz, and
J L Balibrea
June 1974,
Lancet (London, England),
A J Torres, and
L Ortega, and
J Blanco, and
R Fernandez-Durango, and
F Hernandez, and
A Suarez, and
R Cuberes, and
J Sanz, and
J L Balibrea
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