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The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were observed among the two groups. Alkaline as well as acidic intragastric pH had no effect on the antral release of somatostatin in duodenal ulcer patients and controls. In contrast, alkaline intragastric pH was associated with a significantly higher antral gastrin release in duodenal ulcer patients than in controls. Acidic intragastric pH was associated with a significantly smaller inhibition of antral gastrin release in duodenal ulcer patients than in controls. These results suggest that atropinised anaesthetised duodenal patients release gastrin abnormally in the presence of acidic or alkaline intragastric pH and that any inverse relationship between antral gastrin and somatostatin release is uncoupled under these conditions.
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
October 1994,
Digestive diseases and sciences,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
June 1986,
Gut,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
November 1979,
Surgery,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
January 1992,
Digestion,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
January 1981,
Peptides,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
February 1992,
JPMA. The Journal of the Pakistan Medical Association,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
January 1971,
Scandinavian journal of gastroenterology,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
August 1977,
American journal of surgery,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
September 1963,
Current therapeutic research, clinical and experimental,
S L Jensen, and
J J Holst, and
L A Christiansen, and
M H Shokouh-Amiri, and
M Lorentsen, and
H Beck, and
H E Jensen
May 2001,
Zhonghua yi xue za zhi,
