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The effects of di-n-octyltin dichloride (DOTC) on the thymus in mice were studied in dependence on the route of administration. Single administrations of 30, 60 and 120 mg/kg of DOTC i.m. induced a dose-related decrease of the thymus weight and of the number of nucleated cells in the thymus of male mice. 4 days after intravenous injection of 8 mg/kg of DOTC the thymus weight and the number of thymocytes were reduced to 50 percent of the control. In oral route of administration higher doses of DOTC (300 mg/kg) were necessary to provoke a thymus atrophy. After pretreatment of mice with carbon tetrachloride the toxic effects of orally administered DOTC were increased. The reduction of the thymus weight and of the number of thymocytes in mice after parenteral administration was accompanied by a depression of thymus-dependent antibody formation against sheep red blood cells.
G Hennighausen, and
P Lange
January 1989,
International journal of immunopharmacology,
G Hennighausen, and
P Lange
December 1970,
Food and cosmetics toxicology,
G Hennighausen, and
P Lange
August 1986,
Arzneimittel-Forschung,
G Hennighausen, and
P Lange
April 1987,
Toxicology,
G Hennighausen, and
P Lange
November 2011,
Reproductive toxicology (Elmsford, N.Y.),
G Hennighausen, and
P Lange
March 2024,
Toxicology mechanisms and methods,
G Hennighausen, and
P Lange
July 2011,
Toxicology letters,
G Hennighausen, and
P Lange
February 1990,
Toxicology letters,
G Hennighausen, and
P Lange
August 1984,
Die Pharmazie,
G Hennighausen, and
P Lange
October 1995,
Toxicology in vitro : an international journal published in association with BIBRA,
