Itch induces conditioned place aversion in mice. 2017

Di Mu, and Yan-Gang Sun
Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China; University of Chinese Academy of Sciences, 19A Yu-quan Road, Beijing, 100049, China.

Itch sensation consists of both sensory and emotional components. The molecular and cellular mechanisms underlying the transduction and transmission of itch sensation have been studied extensively in rodents. However, whether itch induces emotional responses in mice still remains unknown. We found that pruritogens induced conditioned place aversion (CPA) in mice, and that the CPA lasted for at least two weeks. Disruption of itch signal transmission by depletion of peripheral sensory fibers expressing TRPV1 (transient receptor potential vanilloid subfamily, member 1) attenuated chloroquine-induced CPA. Consistently, ablation of itch-specific neurons that express gastrin-releasing peptide receptor in the spinal cord also abolished itch-induced CPA, confirming that itch-induced CPA is dependent on the spinal itch circuit. Thus, these results demonstrate that itch can induce CPA in mice, which requires peripheral itch signal inputs.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011537 Pruritus An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief. Itching,Pruritis
D011984 Sensory Receptor Cells Specialized afferent neurons capable of transducing sensory stimuli into NERVE IMPULSES to be transmitted to the CENTRAL NERVOUS SYSTEM. Sometimes sensory receptors for external stimuli are called exteroceptors; for internal stimuli are called interoceptors and proprioceptors. Nerve Endings, Sensory,Neurons, Sensory,Neuroreceptors,Receptors, Neural,Neural Receptors,Receptors, Sensory,Sensory Neurons,Sensory Receptors,Nerve Ending, Sensory,Neural Receptor,Neuron, Sensory,Neuroreceptor,Receptor Cell, Sensory,Receptor Cells, Sensory,Receptor, Neural,Receptor, Sensory,Sensory Nerve Ending,Sensory Nerve Endings,Sensory Neuron,Sensory Receptor,Sensory Receptor Cell
D005727 Ganglia, Spinal Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. Dorsal Root Ganglia,Spinal Ganglia,Dorsal Root Ganglion,Ganglion, Spinal,Ganglia, Dorsal Root,Ganglion, Dorsal Root,Spinal Ganglion
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012677 Sensation The process in which specialized SENSORY RECEPTOR CELLS transduce peripheral stimuli (physical or chemical) into NERVE IMPULSES which are then transmitted to the various sensory centers in the CENTRAL NERVOUS SYSTEM. Sensory Function,Organoleptic,Function, Sensory,Functions, Sensory,Sensations,Sensory Functions
D013116 Spinal Cord A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER. Coccygeal Cord,Conus Medullaris,Conus Terminalis,Lumbar Cord,Medulla Spinalis,Myelon,Sacral Cord,Thoracic Cord,Coccygeal Cords,Conus Medullari,Conus Terminali,Cord, Coccygeal,Cord, Lumbar,Cord, Sacral,Cord, Spinal,Cord, Thoracic,Cords, Coccygeal,Cords, Lumbar,Cords, Sacral,Cords, Spinal,Cords, Thoracic,Lumbar Cords,Medulla Spinali,Medullari, Conus,Medullaris, Conus,Myelons,Sacral Cords,Spinal Cords,Spinali, Medulla,Spinalis, Medulla,Terminali, Conus,Terminalis, Conus,Thoracic Cords
D018004 Receptors, Bombesin Cell surface proteins that bind bombesin or closely related peptides with high affinity and trigger intracellular changes influencing the behavior of cells. Gastrin- releasing peptide (GRP); GRP 18-27 (neuromedin C), and neuromedin B are endogenous ligands of bombesin receptors in mammals. Bombesin Receptors,Gastrin-Releasing Peptide Receptors,Neuromedin B Receptors,Receptors, Gastrin-Releasing Peptide,Receptors, Neuromedin B,Bombesin Receptor,Gastrin-Releasing Peptide Receptor,Neuromedin B Receptor,B Receptor, Neuromedin,B Receptors, Neuromedin,Gastrin Releasing Peptide Receptor,Gastrin Releasing Peptide Receptors,Peptide Receptor, Gastrin-Releasing,Peptide Receptors, Gastrin-Releasing,Receptor, Bombesin,Receptor, Gastrin-Releasing Peptide,Receptor, Neuromedin B,Receptors, Gastrin Releasing Peptide
D019886 Gastrin-Releasing Peptide Neuropeptide and gut hormone that helps regulate GASTRIC ACID secretion and motor function. Once released from nerves in the antrum of the STOMACH, the neuropeptide stimulates release of GASTRIN from the GASTRIN-SECRETING CELLS. Gastrin-Releasing Peptide (1-27),Gastrin Releasing Peptide

Related Publications

Di Mu, and Yan-Gang Sun
January 1995, Pharmacology, biochemistry, and behavior,
Di Mu, and Yan-Gang Sun
November 2000, Behavioural pharmacology,
Di Mu, and Yan-Gang Sun
February 2023, Experimental and clinical psychopharmacology,
Di Mu, and Yan-Gang Sun
January 2006, Nature protocols,
Di Mu, and Yan-Gang Sun
January 2014, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi,
Di Mu, and Yan-Gang Sun
June 1993, Behavioral neuroscience,
Copied contents to your clipboard!