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Granulocyte/macrophage progenitor cells (CFU-GM) and erythroid progenitor cells (BFU-E) have been assayed in peripheral blood (PB) and/or bone marrow (BM) from 12 patients with acute lymphocytic leukemia (ALL), 16 patients with chronic lymphocytic leukemia (CLL) and 31 patients with various forms of non-Hodgkin lymphoma (NHL) without BM involvement. Progenitor cell growth in PB and BM from the NHL patients did not differ statistically from controls (p greater than 0.1). CFU-GM and BFU-E per ml PB were markedly increased in ALL and CLL patients (p less than 0.001) while CFU-GM and BFU-E per plated BM cells from these patients were severely depressed (p less than 0.001). Lymphoblasts from one ALL patient failed to inhibit CFU-GM and BFU-E-derived colony growth from control PB mononuclear cells. The high levels of circulating progenitor cells in ALL and CLL patients clearly distinguish them from other cytopenic hematological malignancies, in which decreased progenitor cell levels have been demonstrated previously (acute myeloid leukemia, hairy cell leukemia). The cause of this finding and its pathophysiological implication still remains to be established.
K Geissler, and
W Hinterberger, and
P Bettelheim, and
E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
May 1984,
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K Geissler, and
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E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
April 1983,
International journal of cell cloning,
K Geissler, and
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T Radaszkiewicz, and
W Knapp, and
K Lechner
December 1983,
Cancer research,
K Geissler, and
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E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
February 1996,
Experimental hematology,
K Geissler, and
W Hinterberger, and
P Bettelheim, and
E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
July 1998,
Leukemia & lymphoma,
K Geissler, and
W Hinterberger, and
P Bettelheim, and
E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
December 1996,
Environmental health perspectives,
K Geissler, and
W Hinterberger, and
P Bettelheim, and
E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
January 1978,
Blood cells,
K Geissler, and
W Hinterberger, and
P Bettelheim, and
E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
January 1989,
Acta haematologica,
K Geissler, and
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E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
August 1992,
Blood,
K Geissler, and
W Hinterberger, and
P Bettelheim, and
E Neumann, and
E R Grümayer, and
T Radaszkiewicz, and
W Knapp, and
K Lechner
February 1985,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
