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Certain CNS-active compounds decrease gastric acid secretion in vivo. In this study a number of tricyclic antipsychotic or antidepressant compounds together with haloperidol, a nontricyclic antipsychotic agent, were shown to inhibit dibutyryl-cAMP-stimulated [14C]aminopyrine uptake, an index of acid secretory activity in a rat isolated gastric mucosal cell preparation. The observed order of potency was: thioridazine greater than chlorpromazine greater than haloperidol approximately equal to desipramine approximately equal to imipramine greater than clozapine. Comparison of these potencies with those of the known (H+ + K+)ATPase inhibitors timoprazole and omeprazole revealed that the potency of timoprazole was similar to the one of clozapine while omeprazole was intermediate between thioridazine and chlorpromazine. Pirenzepine was ineffective.
S T Nielsen, and
P A Dove, and
A German, and
C Kuhlman
August 1982,
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S T Nielsen, and
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A German, and
C Kuhlman
September 1984,
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S T Nielsen, and
P A Dove, and
A German, and
C Kuhlman
May 1984,
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S T Nielsen, and
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C Kuhlman
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S T Nielsen, and
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S T Nielsen, and
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C Kuhlman
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S T Nielsen, and
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C Kuhlman
March 1990,
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S T Nielsen, and
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C Kuhlman
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S T Nielsen, and
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C Kuhlman
June 1989,
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S T Nielsen, and
P A Dove, and
A German, and
C Kuhlman
July 1981,
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