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In isolated rat gastric cells somatostatin and PGE2 were compared in respect to their effects on the cAMP system and on the histamine-stimulated H+-production, measured by 14C-aminopyrine (14C-AP) uptake. Like PGE2 somatostatin activated adenylate cyclase (AC) for all in non-parietal cells. This effect on AC declined in cell fractions with increasing number of parietal cells. Activation of AC or elevation of cellular cAMP and uptake of 14C-AP in response to histamine were inhibited by 10(-9) to 10(-5) mol/1 PGE2 and somatostatin. The results indicate remarkable similarity between somatostatin and PGE2: both activate a non-parietal cell AC and both inhibit H+-production, likely by interfering at the histamine sensitive AC of the parietal cell.
W Schepp, and
H K Heim, and
H J Ruoff
August 1982,
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W Schepp, and
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January 1987,
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W Schepp, and
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W Schepp, and
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H J Ruoff
March 1990,
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W Schepp, and
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W Schepp, and
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H J Ruoff
September 1987,
Digestive diseases and sciences,
W Schepp, and
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H J Ruoff
June 1983,
Agents and actions,
W Schepp, and
H K Heim, and
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July 1981,
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W Schepp, and
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W Schepp, and
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