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We have determined the chromosomal location of the human gene for gamma-glutamyltransferase (GGT). This study was done by in situ hybridization of human metaphase spreads with a rat cDNA probe specific for this enzyme and constructed from two clones previously characterized in our laboratory. The final construct had a 1.6-kb-long insert covering 92% of the coding sequence for GGT. The new insert was also freed of any GC tails introduced for the cDNA cloning, because we observed that these sequences were responsible for a high background. Using this probe for the analysis of 136 human metaphase spreads, we observed a strong specific signal on chromosome 22 at the interface of q111-112 and a minor peak in q131. Thus GGT might represent a new marker for the study of certain diseases which have chromosomal abnormalities at these loci.
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
March 1993,
Human genetics,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
May 1986,
Human genetics,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
January 1978,
Cytogenetics and cell genetics,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
July 1990,
Journal of cellular biochemistry,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
November 1984,
American journal of human genetics,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
August 2001,
Critical reviews in clinical laboratory sciences,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
December 1978,
The American journal of medical technology,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
November 1988,
Journal of medical genetics,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
August 1993,
Genomics,
F Bulle, and
M G Mattei, and
S Siegrist, and
A Pawlak, and
E Passage, and
M N Chobert, and
Y Laperche, and
G Guellaën
July 1986,
Annals of human genetics,
