-transparent.png){kind=logo}
The relationship between strongyloidiasis and HTLV-I was investigated in Okinawa, an area where both conditions are endemic. Thirty-six patients with strongyloidiasis were seropositive for HTLV-I and suffered from several related clinical complications. Fourteen of these patients (39%) were shown to have monoclonal integration of HTLV-I proviral DNA in their blood lymphocytes, a condition designated as "smouldering" adult T-cell leukaemia (ATL). Monoclonal integration of proviral DNA correlated with an increased CD4/CD8 ratio and the presence of abnormal lymphocytes in the peripheral blood, and with a trend for greater severity of the parasitic infection. Although the immunodeficiency caused by HTLV-I could predispose to hyperinfestation by Strongyloides, it is also possible that both the parasitic and the retroviral infestations are important co-factors leading to the development of ATL.
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
February 1996,
Leukemia,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
January 1992,
Annals of neurology,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
January 2001,
Dermatology (Basel, Switzerland),
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
August 1994,
Annals of neurology,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
June 1994,
Gene,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
August 1994,
Journal of neuroimmunology,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
January 2003,
Blood cells, molecules & diseases,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
February 1993,
Journal of neuroimmunology,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
November 1991,
The Journal of infectious diseases,
K Nakada, and
K Yamaguchi, and
S Furugen, and
T Nakasone, and
K Nakasone, and
Y Oshiro, and
M Kohakura, and
Y Hinuma, and
M Seiki, and
M Yoshida
February 2005,
Thorax,
