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Of 275 consecutive Haemophilus influenzae type b (Hib) strains isolated from children with invasive disease in Finland in 1985-86, 74% were of the common European outer membrane protein (OMP) subtype 1 and 22% were of OMP subtype 1c, which is usually rare. Strains of subtype 1c caused proportionately more meningitis and less epiglottis than did strains of subtype 1c. Furthermore, children with disease due to strains of subtype 1c were younger than those with disease due to strains of subtype 1. The significant difference in association between subtype and the diagnosis of epiglottitis or meningitis remained even when the strong influence of age was accounted for. This finding may suggest a true difference in the virulence between these subtypes not previously demonstrated for Haemophilus influenzae type b.
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
February 1982,
The Journal of pediatrics,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
July 1993,
The Journal of infectious diseases,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
July 1992,
Journal of clinical microbiology,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
September 1981,
The Journal of infectious diseases,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
January 1993,
Journal of forensic sciences,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
November 1991,
BMJ (Clinical research ed.),
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
October 1993,
Australian family physician,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
November 1981,
The Journal of infectious diseases,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
August 1984,
Journal of clinical microbiology,
A K Takala, and
L van Alphen, and
J Eskola, and
J Palmgren, and
P Bol, and
P H Mäkelä
December 1983,
The Journal of infectious diseases,
