Biomaterial Database

Outer-membrane protein subtypes of Haemophilus influenzae type b and spread of disease in day-care centers. 1981

S J Barenkamp, and D M Granoff, and R S Munson

Isolates of Haemophilus influenzae type b with a distinctive outer-membrane protein subtype, designated 1H, were responsible for 11 of 13 cases of invasive infection in children attending six day-care centers with secondary cases of disease, in comparison to three of 14 cases in children attending 10 centers with single cases and two centers with unrelated cases. The other 11 cases were caused by type b isolates of six different subtypes. The secondary attack rate in contacts younger than four years of age exposed to disease due to isolates of the 1H subtype was 16 per 1,000, compared with 1.6 per 1,000 after exposure to disease caused by subtypes other than 1H (P less than 0.008). Carriage rates were increased in day-care-center contacts exposed to patients with disease, and most of the carriers were colonized by isolates with subtypes homologous to those responsible for the respective index cases. Both 1H and non-1H strains were capable of colonizing contacts, but 1H strains may be more pathogenic than other subtypes.

UI	MeSH Term	Description	Entries
D008565	Membrane Proteins	Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.	Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D009302	Nasopharyngeal Diseases	Pathological processes involving the NASOPHARYNX.	Diseases of Nasopharynx,Disease, Nasopharyngeal,Diseases, Nasopharyngeal,Nasopharyngeal Disease,Nasopharynx Disease,Nasopharynx Diseases
D002656	Child Day Care Centers	Facilities which provide care for pre-school and school-age children.	Day Care Centers for Children,Child Daycare Centers,Daycare Centers for Children,Child Daycare Center
D006192	Haemophilus Infections	Infections with bacteria of the genus HAEMOPHILUS.	Hemophilus Infections,Haemophilus influenzae Infection,Haemophilus influenzae Type b Infection,Hib Infection,Infections, Haemophilus,Infections, Hemophilus,Haemophilus Infection,Haemophilus influenzae Infections,Hemophilus Infection,Hib Infections,Infection, Haemophilus,Infection, Haemophilus influenzae,Infection, Hemophilus,Infection, Hib
D006193	Haemophilus influenzae	A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII.	Bacterium influenzae,Coccobacillus pfeifferi,Haemophilus meningitidis,Hemophilus influenzae,Influenza-bacillus,Mycobacterium influenzae
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001426	Bacterial Proteins	Proteins found in any species of bacterium.	Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial