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To characterize the effect of L-norepinephrine on intracellular pH (pHi) in parotid acinar cells, were measured the accumulation of 14C-labelled 5,5-dimethyloxazolidine-2,4-dione ([14C]DMO), in slices of parotid glands from Sprague-Dawley rats. L-Norepinephrine enhanced the [14C]DMO uptake in a concentration-dependent manner with half-maximal effect at about 1 microM and maximum effect at about 1 mM. The half-maximal effect corresponded to an increase in pHi by 0.08 units and was reduced by 2 microM L-propranolol (beta-adrenoceptor antagonist), but was not affected by 2 microM phentolamine (alpha-adrenoceptor antagonist). The results suggest that L-norepinephrine increases intracellular pH in rat parotid acini and that this effect may be mediated by beta-adrenoceptor stimulation.
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
May 1982,
The American journal of physiology,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
January 1983,
Medical biology,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
June 2009,
Journal of oral science,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
January 1989,
Cell calcium,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
October 1985,
The Biochemical journal,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
January 1980,
Nature,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
April 1987,
The Journal of biological chemistry,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
September 1988,
The Journal of biological chemistry,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
August 1984,
The Biochemical journal,
G Jönsson, and
R Henriksson, and
P Lindström, and
S Sundström
November 1988,
Experimental cell research,
