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Infusion of 2 nmol atrial natriuretic factor (ANF) into the third cerebroventricle of conscious, orchidectomized male rats results in a significant inhibition of prolactin (PRL) secretion. This effect is prevented by prior treatment with the dopamine receptor antagonist, domperidone. Furthermore, domperidone reverses the inhibitory effect when given after ANF infusion. The PRL-inhibiting effect is absent as well following inhibition of tyrosine hydroxylase activity. These results suggest that ANF acts centrally at least in part via an interaction with endogenous dopaminergic systems and further suggests potent neuromodulatory actions of the peptide within the hypothalamus.
W K Samson, and
R Bianchi, and
R Mogg
September 1989,
Cellular and molecular neurobiology,
W K Samson, and
R Bianchi, and
R Mogg
November 1989,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
W K Samson, and
R Bianchi, and
R Mogg
November 1986,
European journal of pharmacology,
W K Samson, and
R Bianchi, and
R Mogg
January 1986,
Neuroendocrinology,
W K Samson, and
R Bianchi, and
R Mogg
August 1995,
The American journal of physiology,
W K Samson, and
R Bianchi, and
R Mogg
January 1991,
Sheng li ke xue jin zhan [Progress in physiology],
W K Samson, and
R Bianchi, and
R Mogg
October 1984,
Biochemical and biophysical research communications,
W K Samson, and
R Bianchi, and
R Mogg
November 1989,
Clinical science (London, England : 1979),
W K Samson, and
R Bianchi, and
R Mogg
July 1991,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
W K Samson, and
R Bianchi, and
R Mogg
February 1985,
FEBS letters,
