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Visible-Light-Mediated Construction of Pyrroloindolines via an Amidyl Radical Cyclization/Carbon Radical Addition Cascade: Rapid Synthesis of (±)-Flustramide B. 2017

Kui Wu, and Yuliu Du, and Ting Wang
Department of Chemistry, University at Albany, State University of New York , 1400 Washington Avenue, Albany, New York 12222, United States.

The development of visible-light-mediated synthesis of pyrroloindolines via an amidyl radical cyclization-carbon radical functionalization cascade is reported. The transformation shows a broad substrate scope, tolerating a variety of substitutions on indole aromatic rings and N-centers. Different functionalized alkene systems could be used as radical acceptors. Relying on this strategy, a rapid synthesis of flustramide B was achieved.

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