Biomaterial Database

Intermediate filaments and cellular mechanics. 2018

Wolfgang H Goldmann

Department of Physics, Biophysics Group, Friedrich-Alexander-University Erlangen-Nuremberg, D-91052 Erlangen, Germany.

Intermediate filaments (IFs) are one of the three types of cytoskeletal polymers that resist tensile and compressive forces in cells. They crosslink each other as well as with actin filaments and microtubules by proteins, which include desmin, filamin C, plectin, and lamin (A/C). Mutations in these proteins can lead to a wide range of pathologies, some of which exhibit mechanical failure of the skin, skeletal, or heart muscle.

UI	MeSH Term	Description	Entries
D007382	Intermediate Filaments	Cytoplasmic filaments intermediate in diameter (about 10 nanometers) between the microfilaments and the microtubules. They may be composed of any of a number of different proteins and form a ring around the cell nucleus.	Tonofilaments,Neurofilaments,Filament, Intermediate,Filaments, Intermediate,Intermediate Filament,Neurofilament,Tonofilament
D003893	Desmin	An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.	Skeletin
D051190	Plectin	A cytoskeletal linker protein with a molecular weight of greater than 500 kDa. It binds INTERMEDIATE FILAMENTS; MICROTUBULES; and ACTIN CYTOSKELETON and plays a central role in the organization and stability of the CYTOSKELETON. Plectin is phosphorylated by CALMODULIN KINASE; PROTEIN KINASE A; and PROTEIN KINASE C.	500-kDa HD1 Protein,Hemidesmosomal Protein HD1,500 kDa HD1 Protein,HD1 Protein, 500-kDa,HD1, Hemidesmosomal Protein
D034904	Lamin Type A	A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.	Lamin A,Lamin A-C,Type A Lamins,Lamin A C,Lamins, Type A
D064448	Filamins	A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.	280 kDa Actin-Binding Protein,Filamin,Filamin 1,Filamin 1-Like Protein,Filamin A,Filamin B,Filamin C,Merofilamins,alpha-Filamin,beta-Filamin,1-Like Protein, Filamin,1-Like Proteins, Filamin,280 kDa Actin Binding Protein,Cs, Filamin,Filamin 1 Like Protein,Filamin 1-Like Proteins,Filamin Cs,Merofilamin,Protein, Filamin 1-Like,Proteins, Filamin 1-Like,alpha Filamin,alpha-Filamins,beta Filamin,beta-Filamins