BIOMAT Database Logo BIOMAT Database Logo

Role of Ti/CD3, Thy-1, and Ly-6 in cytolytic T-cell activation analyzed with Ti loss variants. 1988

C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Centre d'Immunologie INSERM-CNRS de Marseille-Luminy, France.

UI MeSH Term Description Entries
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D010835 Phytohemagglutinins Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture. Kidney Bean Lectin,Kidney Bean Lectins,Lectins, Kidney Bean,Phaseolus vulgaris Lectin,Phaseolus vulgaris Lectins,Phytohemagglutinin,Hemagglutinins, Plant,Lectin, Kidney Bean,Lectin, Phaseolus vulgaris,Lectins, Phaseolus vulgaris,Plant Hemagglutinins
D011948 Receptors, Antigen, T-Cell Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains. Antigen Receptors, T-Cell,T-Cell Receptors,Receptors, T-Cell Antigen,T-Cell Antigen Receptor,T-Cell Receptor,Antigen Receptor, T-Cell,Antigen Receptors, T Cell,Receptor, T-Cell,Receptor, T-Cell Antigen,Receptors, T Cell Antigen,Receptors, T-Cell,T Cell Antigen Receptor,T Cell Receptor,T Cell Receptors,T-Cell Antigen Receptors
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D002999 Clone Cells A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed) Clones,Cell, Clone,Cells, Clone,Clone,Clone Cell
D003208 Concanavalin A A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D000945 Antigens, Differentiation, T-Lymphocyte Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function. Antigens, Differentiation, T-Cell,Differentiation Antigens, T-Cell,L3T4 Antigens,Leu Antigens, T-Lymphocyte,T-Cell Differentiation Antigens,T-Lymphocyte Differentiation Antigens,T6 Antigens,Antigens, Differentiation, T Lymphocyte,Differentiation Antigens, T Lymphocyte,Antigens, L3T4,Antigens, T-Cell Differentiation,Antigens, T-Lymphocyte Differentiation,Antigens, T-Lymphocyte Leu,Antigens, T6,Differentiation Antigens, T Cell,Differentiation Antigens, T-Lymphocyte,Leu Antigens, T Lymphocyte,T Cell Differentiation Antigens,T Lymphocyte Differentiation Antigens,T-Lymphocyte Leu Antigens

Related Publications

C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex.
January 1987, Nature,
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Genetic basis for Ly-6- defect: complementation between Ly-6- and Thy-1- mutant cell lines.
January 1983, Immunogenetics,
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies.
September 1986, The Journal of experimental medicine,
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Acute Trypanosoma cruzi infection differentially affects CD3 and Thy-1 mediated T cell activation.
June 1991, Immunology letters,
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors.
April 1978, The Journal of experimental medicine,
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
T cell receptor/CD3 negative variants are unresponsive to stimulation through the Ly-6 encoded molecule, TAP.
September 1988, Journal of immunology (Baltimore, Md. : 1950),
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Thy-1-negative and Ly-1-negative variants of T cells produce interleukin 2 in response to mitogens.
July 1987, Journal of immunology (Baltimore, Md. : 1950),
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Squid glycoproteins with structural similarities to Thy-1 and Ly-6 antigens.
January 1988, Immunogenetics,
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Role of Thy-1 in T cell development.
December 1997, Journal of immunology (Baltimore, Md. : 1950),
C Langlet, and A Guimezanes, and P Kaldy, and C Boyer, and M Buferne, and M Poenie, and R Tsien, and O Leo, and J Bluestone, and L Leserman
Genetic linkage of Ly-6 and Thy-1 loci in the mouse.
January 1980, Immunogenetics,
Copied contents to your clipboard!