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A Manganese Pre-Catalyst: Mild Reduction of Amides, Ketones, Aldehydes, and Esters. 2017

Colin M Kelly, and Robert McDonald, and Orson L Sydora, and Mark Stradiotto, and Laura Turculet
Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada.

A new (N-phosphinoamidinate)manganese complex is shown to be a useful pre-catalyst for the hydrosilative reduction of carbonyl compounds, and in most cases at room temperature. The Mn-catalyzed reduction of tertiary amides to tertiary amines, with a useful scope, is demonstrated for the first time by use of this catalyst, and is competitive with the most effective transition-metal catalysts known for such transformations. Ketones, aldehydes, and esters were also successfully reduced under mild conditions by using this new Mn catalyst.

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