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Concentrations of immunoreactive insulin and of glucose were measured in plasma samples taken at 4-hour intervals from cirrhotic and normal control subjects ingesting diets containing various amounts of protein. In both groups, insulin levels were highest after meals, between 11 a.m. and 7 p.m.; in cirrhotic subjects, but not in controls, plasma glucose levels were also higher at these times. Insulin and glucose concentrations in plasma from cirrhotic subjects were higher than those from control subjects at all times measured. Peak daytime insulin levels were about 150 muU/ml in plasma from cirrhotic subjects, and 40--50 muU/ml in plasma from controls; nocturnal levels were 20--30 muU/ml in cirrhotics versus 10 muU/ml or less in controls. The protein content of the diet was unrelated to plasma insulin levels at all times of day or night examined. These data thus show that plasma insulin levels are persistently elevated in cirrhotics, remaining higher than normal throughout the 24-hour period.
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
September 1979,
The American journal of clinical nutrition,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
November 1981,
Bollettino della Societa italiana di biologia sperimentale,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
September 1979,
The American journal of clinical nutrition,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
April 1977,
Atherosclerosis,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
November 1981,
Bollettino della Societa italiana di biologia sperimentale,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
January 1959,
Scandinavian journal of clinical and laboratory investigation,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
November 1978,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
July 1978,
Clinica chimica acta; international journal of clinical chemistry,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
January 1980,
Acta diabetologica latina,
J D Fernstrom, and
M A Arnold, and
R J Wurtman, and
B Hammarstrom-Wiklund, and
H N Munro, and
C S Davidson
January 1975,
Hormone research,
