Molecular prevalence of spotted fever group rickettsiae in ticks from Qinghai Province, northwestern China. 2018

Rong Han, and Jifei Yang, and Qingli Niu, and Zhijie Liu, and Ze Chen, and Wei Kan, and Guangwei Hu, and Guangyuan Liu, and Jianxun Luo, and Hong Yin
State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Xujiaping 1, Lanzhou, Gansu 730046, PR China; Qinghai Provincial Center for Animal Disease Control and Prevention, Xining, 810003, Qinghai, PR China.

Tick-borne rickettsioses is one of the oldest known vector-borne diseases and has been viewed as emerging or re-emerging disease in China. The causative agents have been increasingly recognized and exhibited a high degree of genetic diversity and widespread distribution. This study was conducted to determine the prevalence of spotted fever group rickettsiae in ticks from Qinghai Province, northwestern China. In total, 860 questing adult ticks representing six species were collected. The SFG rickettsiae were detected in Haemaphysalis qinghaiensis (19.6%, 79/404), Dermacentor abaensis (73.7%, 157/213), Dermacentor silvarum (50.0%, 47/94), Dermacentor nuttalli (67.4%, 97/144), and Ixodes crenulatus (100%, 3/3), with an overall infection rate of 44.5%. The infection rates of SFG rickettsiae were significantly higher in Dermacentor spp. than in Haemaphysalis spp. (p<0.05). Sequence analyses of the gltA and ompA genes revealed that five SFG rickettsiae are present in ticks in Qinghai, including R. sibirica subspecies sibirica, R. raoultii, "Candidatus Rickettsia tibetani", and "Candidatus Rickettsia gannanii" Y27 and F107. Moreover, a potential novel Rickettsia species (Rickettsia sp. 10CYF) was identified in D. nuttalli and I. crenulatus. These findings extend our knowledge of the potential vector spectrum and distribution of rickettsiae, and provided valuable information for assessing the potential risk for public health.

UI MeSH Term Description Entries
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D005798 Genes, Bacterial The functional hereditary units of BACTERIA. Bacterial Gene,Bacterial Genes,Gene, Bacterial
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000073605 Spotted Fever Group Rickettsiosis A group of arthropod-borne diseases caused by spotted fever bio-group members of RICKETTSIA. They are characterized by fever, headache, and petechial (spotted) rash. Rickettsialpox,African Tick-Bite Fever,Far Eastern Spotted Fever,Flinders Island Spotted Fever,Japanese Spotted Fever,North Asian Tick Typhus,Queensland Tick Typhus,Rickettsia aeschlimannii Infection,Rickettsia africae Infection,Rickettsia akari Infection,Rickettsia australis Infection,Rickettsia slovaca Infection,Spotted Fever Group Rickettsioses,Spotted Fevers,TIBOLA,Tick-Borne Lymphadenopathy,African Tick Bite Fever,Fever, African Tick-Bite,Fever, Japanese Spotted,Fever, Spotted,Fevers, Japanese Spotted,Fevers, Spotted,Infection, Rickettsia aeschlimannii,Infection, Rickettsia africae,Infection, Rickettsia akari,Infection, Rickettsia australis,Infection, Rickettsia slovaca,Infections, Rickettsia aeschlimannii,Infections, Rickettsia africae,Infections, Rickettsia akari,Infections, Rickettsia australis,Infections, Rickettsia slovaca,Japanese Spotted Fevers,Lymphadenopathies, Tick-Borne,Lymphadenopathy, Tick-Borne,Rickettsia aeschlimannii Infections,Rickettsia africae Infections,Rickettsia akari Infections,Rickettsia australis Infections,Rickettsia slovaca Infections,Spotted Fever,Spotted Fever, Japanese,Tick Borne Lymphadenopathy,Tick Typhus, Queensland,Tick-Bite Fever, African,Tick-Borne Lymphadenopathies,Typhus, Queensland Tick
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012281 Rickettsia A genus of gram-negative, aerobic, rod-shaped bacteria often surrounded by a protein microcapsular layer and slime layer. The natural cycle of its organisms generally involves a vertebrate and an invertebrate host. Species of the genus are the etiological agents of human diseases, such as typhus.
D013987 Ticks Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44) Ixodida,Ixodidas,Tick
D015995 Prevalence The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. Period Prevalence,Point Prevalence,Period Prevalences,Point Prevalences,Prevalence, Period,Prevalence, Point,Prevalences

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