-transparent.png){kind=logo}
We have used an antibody that cross-reacts with cholecystokinin-33/39 to measure cholecystokinin release into plasma; this release was correlated with simultaneous measurements of gallbladder pressure and pancreatic protein secretion in response to intestinal administration of fat. Nine conscious dogs were prepared with chronic gastric, pancreatic, and gallbladder fistulas. Plasma cholecystokinin, gallbladder pressure, and pancreatic protein output were measured simultaneously before, and at intervals during, a 2-h intraduodenal infusion of sodium oleate. This infusion resulted in significant (p less than 0.05) elevations of plasma cholecystokinin (from 64 +/- 7 to 181 +/- 27 pg/ml), in gallbladder pressure (from 13 +/- 1 to 27 +/- 3 cmH2O), and in pancreatic protein output (from 65 +/- 7 to 148 +/- 21 mg/15 min); all measurements are from the basal state to 120 min after the onset of duodenal perfusion. Plasma concentrations of cholecystokinin were significantly correlated with gallbladder pressure (r = 0.91, p less than 0.05) and pancreatic protein output (r = 0.84, p less than 0.05). These data provide evidence that release of endogenous cholecystokinin, as measured by radioimmunoassay, can be correlated with the classic biologic actions ascribed to cholecystokinin.
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
March 1989,
Digestive diseases and sciences,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
November 1984,
Surgery, gynecology & obstetrics,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
January 1988,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
January 1988,
Surgery, gynecology & obstetrics,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
July 1992,
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
August 1988,
Irish journal of medical science,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
July 1991,
Pancreas,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
January 1998,
Arzneimittel-Forschung,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
January 1977,
Surgical forum,
G M Fried, and
W D Ogden, and
J Swierczek, and
G H Greeley, and
P L Rayford, and
J C Thompson
March 1994,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
