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We measured brain energy phosphate metabolism and intracellular pH (pHi) in a cross-sectional study of migraine patients by in vivo phosphorus 31 NMR spectroscopy. During a migraine attack the ratio ATP/total phosphate signal (mole % ATP) was preserved, but there was a decrease in mole % phosphocreatine (PCr) and an increase in mole % inorganic phosphate (Pi) resulting in a decrease of the PCr/Pi ratio, an index of brain phosphorylation potential. This was found in classic but not common migraine. Mole % Pi was also increased in combined brain regions between attacks. There was no alteration in brain pHi during or between attacks. Energy phosphate metabolism but not pHi appears disordered during a migraine attack.
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
June 1994,
British journal of cancer,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
August 2000,
Science in China. Series C, Life sciences,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
August 1984,
Lancet (London, England),
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
April 1987,
Biochemical and biophysical research communications,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
October 1990,
Cephalalgia : an international journal of headache,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
July 1991,
Cephalalgia : an international journal of headache,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
November 2003,
American journal of physiology. Heart and circulatory physiology,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
October 1992,
Acta neurologica Scandinavica,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
November 1995,
Neuroreport,
K M Welch, and
S R Levine, and
G D'Andrea, and
L R Schultz, and
J A Helpern
January 1990,
International journal of cardiac imaging,
