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Orychophragines A-C, Three Biologically Active Alkaloids from Orychophragmus violaceus. 2018
Guang-Jie Zhang, and
Bin Li, and
Hui-Min Cui, and
Li Chen, and
Ying Tian, and
Shi-Jun Liu, and
Bo-Wen Li, and
Min Li, and
Zi-Ming Xia, and
Xing-Xiang Chen, and
Yong Hou, and
Jun-Xing Dong
Beijing Institute of Radiation Medicine , Beijing 100850, People's Republic of China.
Orychophragines A-C (1-3), three new alkaloids with an novel 2-piperazinone-fused 2,4-dioxohexahydro-1,3,5-triazine skeleton, were isolated from the seeds of Orychophragmus violaceus. Their structures were established on the basis of spectroscopic analysis and X-ray crystallographic analysis. Orychophragines A (1) exhibited remarkable cytotoxicity against HepG2, A549, Hela, and HCT-116 cells with IC50 values of 7.73, 10.79, 11.91, and 9.93 μM, respectively. Orychophragines C (3) showed moderate 60Co γ radiation protection activity in HUVEC cells. A plausible biosynthetic pathway for 1-3 was proposed.
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